Perfeziona i miei risultati

Document type

Institution

Collection spécifique

Lingua

Parola chiave

Université de Fribourg

Role for glutathione in the hyposensitivity of LPS-pretreated mice to LPS anorexia

Hernadfalvi, Noemi ; Langhans, Wolfgang ; Meyenburg, Claudia von ; Onteniente, Brigitte ; Richard, Denis ; Arsenijevic, Denis

In: European Cytokine Network, 2007, vol. 18, no. 2, p. 39-45

To study the role of the redox state regulator glutathione (GSH) in bacterial lipopolysaccharide (LPS)-induced anorexia we measured GSH in liver, serum and brain in response to intraperitoneal (ip) lipopolysaccharide (LPS, 4μg/mouse) injection in LPS-naïve and LPS-pretreated (4 μg/mouse) mice. LPS reduced food intake in LPS-naïve mice and LPS pretreatment attenuated this effect. LPS...

Université de Fribourg

Role for nerve growth factor in the in vivo regulation of glutathione in response to LPS in mice

Arsenijevic, Denis ; Hernadfalvi, Noemi ; Meyenburg, Claudia von ; Onteniente, Brigitte ; Richard, Denis ; Langhans, Wolfgang

In: European Cytokine Network, 2007, vol. 18, no. 2, p. 47-55

Since the redox state regulator glutathione (GSH) influences lipopolysaccharide (LPS) anorexia, we studied the roles of tumour necrosis factor-alpha (TNFα) and nerve growth factor (NGF) in the GSH response to intraperitoneal (ip) LPS injection in mice. Basal NGF and GSH levels were up-regulated in brain and liver of TNFα-knock-out (KO) mice, and this was associated with attenuated LPS anorexia....