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In vivo over-expression of interleukin-10 increases resistance to focal brain ischemia in mice

Bilbao, Fabienne de ; Arsenijevic, Denis ; Moll, Thomas ; Garcia-Gabay, Irene ; Vallet, Philippe ; Langhans, Wolfgang ; Giannakopoulos, Panteleimon

In: Journal of Neurochemistry, 2009///doi: 10.1111/j.1471-4159.2009.06098.x

Early studies showed that the administration of the anti-inflammatory cytokine interleukin-10 (IL10) protects against permanent middle cerebral artery occlusion (MCAO) in mice. In this study, transgenic mice expressing murine IL10 (IL10T) directed by the major histocompatibility complex Ea promoter were produced and used to explore the effect of chronically increased IL10 levels on MCAO-related...