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Systematic analysis of synergistic proteome modulations in a drug combination of cisplatin and MLN4924

Megger, Dominik Andre ; Abou-Eid, Shadi ; Zülch, Birgit ; Sitek, Barbara

In: Molecular Omics, 2018, vol. 14, no. 6, p. 450–457

Chemotherapeutic treatment regimens often take advantage of synergistic effects of drug combinations. Anticipating that synergistic effects on the cell biological level likely manifest on the proteome level, the analysis of proteome modulations represents an appropriate strategy to study drug combinations on a molecular level. More specifically, the detection of single proteins exhibiting...