Consortium of Swiss Academic Libraries

Transgenic mice and their impact on kidney research

Rubera, Isabelle ; Hummler, Edith ; Beermann, Friedrich

In: Pflügers Archiv - European Journal of Physiology, 2009, vol. 458, no. 1, p. 211-222

Consortium of Swiss Academic Libraries

Modeling multiple sclerosis in laboratory animals

Schreiner, Bettina ; Heppner, Frank ; Becher, Burkhard

In: Seminars in Immunopathology, 2009, vol. 31, no. 4, p. 479-495

Université de Neuchâtel

Principles of targeted mutagenesis in the moss Physcomitrella patens

Schaefer, Didier G. ; Zrÿd, Jean-Pierre

In: New Frontiers in Bryology:Physiology, Molecular Biology & Applied Genomics, 2004, vol. 4, p. 37-49

Highly efficient gene targeting is a unique feature of the moss Physcomitrella patens. It is now possible, in a multicellular eukaryote, to use the gene replacement technology which has been so successful in yeast. Careful design of transforming vector is nevertheless a key to successful generation of specific mutations.

Université de Neuchâtel

Comparison of gene targeting efficiencies in two mosses suggests that it is a conserved feature of Bryophyte transformation

Trouiller, Bénédicte ; Charlot, Florence ; Choinard, Sandrine ; Schaefer, Didier G. ; Nogué, Fabien

In: Plant Systematics and Evolution, 2007, vol. 29, no. 10, p. 1591-1598

The moss, Physcomitrella patens, is a novel tool in plant functional genomics due to its exceptionally high gene targeting efficiency that is so far unique for plants. To determine if this high gene targeting efficiency is exclusive to P. patens or if it is a common feature to mosses, we estimated gene-targeting efficiency in another moss, Ceratodon purpureus. We transformed...