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Université de Fribourg

The daily rhythm of mice

Ripperger, Jürgen A. ; Jud, Corinne ; Albrecht, Urs

In: FEBS Letters, 2011, p. -

The house mouse Mus musculus represents a valuable tool for the analysis and the understanding of the mammalian circadian oscillator. Forward and reverse genetics allowed the identification of clock components and the verification of their function within the circadian clockwork. In many cases unforeseen links were discovered between a particular circadian regulatory protein and various diseases...

Université de Fribourg

High amplitude phase resetting in Rev-Erba/Per1 double mutant mice

Jud, Corinne ; Hayoz, Antoinette ; Albrecht, Urs

In: PLoS ONE, 2010, vol. 5, no. 9, p. e12540

Over time, organisms developed various strategies to adapt to their environment. Circadian clocks are thought to have evolved to adjust to the predictable rhythms of the light-dark cycle caused by the rotation of the Earth around its own axis. The rhythms these clocks generate persist even in the absence of environmental cues with a period of about 24 hours. To tick in time, they continuously...

Université de Fribourg

The influence of light on the circadian clock of mice and men

Jud, Corinne ; Albrecht, Urs (Dir.)

Thèse de doctorat : Université de Fribourg, 2009 ; Nr. 1625.

The continuous light-dark cycles caused by the rotation of the Earth around its own axis facilitated the evolution of circadian clocks, which have a huge impact on our daily life. Deregulation of the internal clock can lead to sleeping disorders, depression and various other health problems. Thus it is important to understand the mechanisms which allow our clock to tick properly. Since circadian...

Université de Fribourg

Age-dependent alterations in human PER2 levels after early morning blue light exposure

Jud, Corinne ; Chappuis, Sylvie ; Revell, Victoria L. ; Sletten, Tracey L. ; Saaltink, Dirk-Jan ; Cajochen, Christian ; Skene, Debra J. ; Albrecht, Urs

In: Chronobiology International, 2009, vol. 26, no. 7, p. 1462-1469

In our modern society, we are exposed to different artificial light sources that could potentially lead to disturbances of circadian rhythms and, hence, represent a risk for health and welfare. Investigating the acute impact of light on clock-gene expression may thus help us to better understand the mechanisms underlying disorders rooted in the circadian system. Here, we show an overall...

Université de Fribourg

TNF-α suppresses the expression of clock genes by interfering with E-box-mediated transcription

Cavadini, Gionata ; Petrzilka, Saskia ; Kohler, Philipp ; Jud, Corinne ; Tobler, Irene

In: Proceedings of the National Academy of Sciences of the United States of America, 2007, vol. 104, no. 31, p. 12843-12848

Production of TNF-α and IL-1 in infectious and autoimmune diseases is associated with fever, fatigue, and sleep disturbances, which are collectively referred to as sickness behavior syndrome. In mice TNF-α and IL-1 increase nonrapid eye movement sleep. Because clock genes regulate the circadian rhythm and thereby locomotor activity and may alter sleep architecture we assessed the influence of...

Université de Fribourg

Mutation of the circadian clock gene Per2 alters vascular endothelial function

Viswambharan, Hema ; Carvas, João Miguel ; Antic, Vladan ; Marecic, Ana ; Jud, Corinne ; Zaugg, Christian E. ; Ming, Xiu-Fen ; Montani, Jean-Pierre ; Albrecht, Urs ; Yang, Zhihong

In: Circulation, 2007, vol. 115, p. 2188-2195

Background— The circadian clock regulates biological processes including cardiovascular function and metabolism. In the present study, we investigated the role of the circadian clock gene Period2 (Per2) in endothelial function in a mouse model. Methods and Results— Compared with the wild-type littermates, mice with Per2 mutation exhibited impaired...

Université de Fribourg

A guideline for analyzing circadian wheel-running behavior in rodents under different lighting conditions

Jud, Corinne ; Schmutz, Isabelle ; Hampp, Gabriele ; Oster, Henrik ; Albrecht, Urs

In: Biological Procedures Online, 2005, vol. 7, p. 101-116

Most behavioral experiments within circadian research are based on the analysis of locomotor activity. This paper introduces scientists to chronobiology by explaining the basic terminology used within the field. Furthermore, it aims to assist in designing, carrying out, and evaluating wheel-running experiments with rodents, particularly mice. Since light is an easily applicable stimulus that...

Université de Fribourg

Evening exposure to blue light stimulates the expression of the clock gene PER2 in humans

Cajochen, Christian ; Jud, Corinne ; Münch, Mirjam ; Kobialka, Szymon ; Wirz-Justice, Anna ; Albrecht, Urs

In: European Journal of Neuroscience, 2006, vol. 23, no. 4, p. 1082-1086

We developed a non-invasive method to measure and quantify human circadian PER2 gene expression in oral mucosa samples and show that this gene oscillates in a circadian (= about a day) fashion. We also have the first evidence that induction of human PER2 expression is stimulated by exposing subjects to 2 h of light in the evening. This increase in PER2 expression was statistically significant...

Université de Fribourg

Circadian rhythms in murine pups develop in absence of a functional maternal circadian clock

Jud, Corinne ; Albrecht, Urs

In: Journal of Biological Rhythms, 2006, vol. 21, no. 2, p. 149-154

A genetic approach was used to investigate whether the emergence of circadian rhythms in murine pups is dependent on a functional maternal clock. Arrhythmic females bearing either the mPer1Brdm1/Per2Brdm1 or mPer2Brdm1/Cry1-/- double-mutant genotype were crossed with wild-type males under constant darkness. The heterozygous offspring have the genetic...