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Université de Fribourg

Exposure of silver-nanoparticles and silver-ions to lung cells in vitro at the air-liquid interface

Herzog, Fabian ; Clift, Martin JD ; Piccapietra, Flavio ; Behra, Renata ; Schmid, Otmar ; Petri-Fink, Alke ; Rothen-Rutishauser, Barbara

In: Particle and Fibre Toxicology, 2013, vol. 10, no. 1, p. 11

Background Due to its antibacterial properties, silver (Ag) has been used in more consumer products than any other nanomaterial so far. Despite the promising advantages posed by using Ag-nanoparticles (NPs), their interaction with mammalian systems is currently not fully understood. An exposure route via inhalation is of primary concern for humans in an occupational setting. Aim of this study was...

Université de Fribourg

Risk assessment of released cellulose nanocrystals – mimicking inhalatory exposure

Endes, Carola ; Müller, S. ; Schmid, O. ; Vanhecke, Dimitri ; Foster, E. Johan ; Petri-Fink, Alke ; Rothen-Rutishauser, Barbara ; Weder, Christoph ; Clift, Martin J. D.

In: Journal of Physics: Conference Series, 2013, vol. 429, no. 1, p. 012008

Cellulose nanocrystals (CNCs) exhibit advantageous chemical and mechanical properties that render them attractive for a wide range of applications. During the life-cycle of CNC containing materials the nanocrystals could be released and become airborne, posing a potential inhalatory exposure risk towards humans. Absent reliable and dose-controlled models that mimic this exposure in situ is a...

Université de Fribourg

Nanomaterials and the human lung: what is known and what must be deciphered to realise their potential advantages?

Jud, Corinne ; Clift, Martin J.D. ; Petri-Fink, Alke ; Rothen-Rutishauser, Barbara

In: Swiss Medical Weekly, 2013, p. -

Due to the constant expansion within the nanotechnology industry in the last decade, nanomaterials are omnipresent in society today. Nanotechnology-based products have numerous different applications ranging from electronic (e.g., advanced memory chips) to industrial (e.g., coatings or composites) to biomedical (e.g., drug delivery systems, diagnostics). Although these new nanomaterials can be...

Université de Fribourg

Spatial SPION localization in liposome membranes

Bonnaud, Cécile ; Vanhecke, Dimitri ; Demurtas, Davide ; Rothen-Rutishauser, Barbara ; Petri-Fink, Alke

In: IEEE Transactions on Magnetics, 2012, vol. 49, no. 1, p. 166-171

Nanocarriers, including liposomes, offer great opportunities for targeted and controlled therapy. The development in this field has led to a large panel of drug delivery systems, which can be classified into 3 different nanovector generations. However, the success of such smart materials requires the control of a large variety of properties and parameters. Unfortunately, characterization at the...

Université de Fribourg

Nanoparticles and cells: an interdisciplinary approach

Petri-Fink, Alke ; Rothen-Rutishauser, Barbara

In: Chimia, 2012, vol. 66, no. 3, p. 104-109

In this article we present an overview of some of our research in the field of nanoscience. By combining two different scientific backgrounds (chemistry and biology), we investigate nanoparticle-cell interactions from different angles. This requires an interdisciplinary approach involving material synthesis and characterization, cell biology (biochemistry) and microscopy. In particular, we...

Université de Fribourg

Influence of serum supplemented cell culture medium on colloidal stability of polymer coated iron oxide and polystyrene nanoparticles with impact on cell interactions in vitro

Hirsch, Vera ; Salaklang, Jatuporn ; Rothen-Rutishauser, Barbara ; Petri-Fink, Alke

In: IEEE Transactions on Magnetics, 2012, vol. 49, no. 1, p. 402-407

When nanoparticles interact with cells, the possible cellular responses to the particles depend on an array of parameters, in both particle and biological aspects. On the one hand, the physicochemical properties of the particles (e.g., material, size, shape, and surface charge) are known to play a key role in particle-cell interactions. On the other hand, it has been shown that prior to coming...

Université de Fribourg

Improved dynamic response assessment for intra-articular injected iron oxide nanoparticles

Crowe, L. A. ; Tobalem, F. ; Gramoun, A. ; Delattre, B. M. A. ; Grosdemange, K. ; Salaklang, Jatuporn ; Redjem, A. ; Petri-Fink, Alke ; Hofmann, Heinrich ; Vallée, J.-P.

In: Magnetic Resonance in Medicine, 2012, vol. 68, no. 5, p. 1544–1552

The emerging importance of nanoparticle technology, including iron oxide nanoparticles for monitoring development, progression, and treatment of inflammatory diseases such as arthritis, drives development of imaging techniques. Studies require an imaging protocol that is sensitive and quantifiable for the detection of iron oxide over a wide range of concentrations. Conventional signal loss...

Université de Fribourg

Biomedical nanoparticles modulate specific CD4+ T cell stimulation by inhibition of antigen processing in dendritic cells

Blank, Fabian ; Gerber, Peter ; Rothen-Rutishauser, Barbara ; Sakulkhu, Usawadee ; Salaklang, Jatuporn ; Peyer, Karin De ; Gehr, Peter ; Nicod, Laurent P. ; Hofmann, Heinrich ; Geiser, Thomas ; Petri-Fink, Alke ; Garnier, Christophe Von

In: Nanotoxicology, 2011, p. -

Understanding how nanoparticles may affect immune responses is an essential prerequisite to developing novel clinical applications. To investigate nanoparticle-dependent outcomes on immune responses, dendritic cells (DCs) were treated with model biomedical poly(vinylalcohol)-coated super-paramagnetic iron oxide nanoparticles (PVA-SPIONs). PVA-SPIONs uptake by human monocyte-derived DCs (MDDCs)...