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    Université de Fribourg

    Ecdysone triggered PGRP‐LC expression controls Drosophila innate immunity

    Rus, Florentina ; Flatt, Thomas ; Tong, Mei ; Aggarwal, Kamna ; Okuda, Kendi ; Kleino, Anni ; Yates, Elisabeth ; Tatar, Marc ; Silverman, Neal

    In: The EMBO Journal, 2013, vol. 32, no. 11, p. 1626–1638

    Throughout the animal kingdom, steroid hormones have been implicated in the defense against microbial infection, but how these systemic signals control immunity is unclear. Here, we show that the steroid hormone ecdysone controls the expression of the pattern recognition receptor PGRP‐LC in Drosophila, thereby tightly regulating innate immune recognition and defense against bacterial...