In: Bioinformatics, 2018, vol. 34, no. 1, p. 107-108
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In: Cancer and Metastasis Reviews, 2009, vol. 28, no. 1-2, p. 15-33
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In: Angiogenesis, 2013, vol. 16, no. 2, p. 455-468
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In: Angiogenesis, 2008, vol. 11, no. 1, p. 53-62
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In: Angiogenesis, 2013, vol. 16, no. 4, p. 795-807
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In: Carcinogenesis, 2010, vol. 31, no. 8, p. 1465-1474
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In: Oncotarget, 2015, vol. 7, no. 2, p. 1663–1674
The significance of matricellular proteins during development and cancer progression is widely recognized. However, how these proteins actively contribute to physiological development and pathological cancer progression is only partially elucidated. In this study, we investigated the role of the matricellular protein Cysteine-rich 61 (CYR61) in pancreatic islet development and carcinogenesis....
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In: Angiogenesis, 2015, vol. 18, no. 3, p. 327–345
Tumor growth depends on the formation of new blood vessels (tumor angiogenesis) either from preexisting vessels or by the recruitment of bone marrow-derived cells. Despite encouraging results obtained with preclinical cancer models, the therapeutic targeting of tumor angiogenesis has thus far failed to deliver an enduring clinical response in cancer patients. One major obstacle for improving...
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In: Seminars in Cancer Biology, 2012, p. -
The ability of tumor cells to leave a primary tumor, to disseminate through the body, and to ultimately seed new secondary tumors is universally agreed to be the basis for metastasis formation. An accurate description of the cellular and molecular mechanisms that underlie this multistep process would greatly facilitate the rational development of therapies that effectively allow metastatic...
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In: Cancer Research, 2011, vol. 71, no. 11, p. 3781-3791
Tumor-mobilized bone marrow-derived CD11b+ myeloid cells promote tumor angiogenesis, but how and when these cells acquire proangiogenic properties is not fully elucidated. Here we show that CD11b+ myelomonocytic cells develop proangiogenic properties during their differentiation from CD34+ hematopoietic progenitors and that Placenta Growth Factor (PlGF) is critical in promoting this ...
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