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Cyclosporine A-sensitive, cyclophilin B-dependent endoplasmic reticulum-associated degradation

Bernasconi, Riccardo ; Soldà, Tatiana ; Galli, Carmela ; Pertel, Thomas ; Luban, Jeremy ; Molinari, Maurizio

In: Plos one, 2010, vol. 5, no. 9, p. e13008

Peptidyl-prolyl cis/trans isomerases (PPIs) catalyze cis/trans isomerization of peptide bonds preceding proline residues. The involvement of PPI family members in protein refolding has been established in test tube experiments. Surprisingly, however, no data is available on the involvement of endoplasmic reticulum (ER)-resident members of the PPI family in protein folding, quality control or...