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Progressive signaling changes in the olfactory nerve of patients with Alzheimer’s disease

Bathini, Praveen ; Mottas, Antoine ; Jaquet, Muriel ; Brai, Emanuele ; Alberi, Lavinia

In: Neurobiology of Aging, 2019, vol. 76, p. 80–95

Olfaction declines with aging and appears to be a prodromal sign of cognitive decline in progressive neurodegenerative diseases. Nevertheless, very little is known about the pathophysiological changes underlying smell loss that may reflect early network dysfunction. A cross-sectional histoanatomical study was conducted on postmortem olfactory nerves of patients with increasing severity of...