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Université de Fribourg

Magi1, a new potential tumor suppressor gene in estrogen receptor positive breast cancer

Alday-Parejo, Begoña ; Richard, François ; Wörthmüller, Janine ; Rau, Tilman ; Galván, José A. ; Desmedt, Christine ; Santamaria-Martinez, Albert ; Rüegg, Curzio

In: Cancers, 2020, vol. 12, no. 1, p. 223

Membrane-associated guanylate kinase (MAGUK) with inverted domain structure-1 (MAGI1) is an intracellular adaptor protein that stabilizes epithelial junctions consistent with a tumor suppressive function in several cancers of epithelial origin. Here we report, based on experimental results and human breast cancer (BC) patients’ gene expression data, that MAGI1 is highly expressed and acts...

Université de Fribourg

Are integrins still practicable targets for anti-cancer therapy?

Alday-Parejo, Begoña ; Stupp, Roger ; Rüegg, Curzio

In: Cancers, 2019, vol. 11, no. 7, p. 978

Correlative clinical evidence and experimental observations indicate that integrin adhesion receptors, in particular those of the αV family, are relevant to cancer cell features, including proliferation, survival, migration, invasion, and metastasis. In addition, integrins promote events in the tumor microenvironment that are critical for tumor progression and metastasis, including tumor...

Université de Fribourg

Mechanism of irradiation-induced mammary cancer metastasis: A role for SAP-dependent Mkl1 signaling

Asparuhova, Maria B. ; Secondini, Chiara ; Rüegg, Curzio ; Chiquet-Ehrismann, Ruth

In: Molecular Oncology, 2015, vol. 9, no. 8, p. 1510–1527

Radiotherapy is a standard treatment after conservative breast cancer surgery. However, cancers relapsing within a previously irradiated area have an increased probability to metastasize. The mechanisms responsible for this aggressiveness remain unclear. Here, we used the clinically relevant 4T1 breast cancer model mimicking aggressive local relapse after radiotherapy to identify differences...

Université de Fribourg

Inhibition of cell migration and invasion mediated by the TAT-RasGAP317–326 peptide requires the DLC1 tumor

Barras, D ; Lorusso, Girieca ; Rüegg, Curzio ; Widmann, Christian

In: Oncogene, 2014, p. -

TAT-RasGAP317–326, a peptide corresponding to the 317–326 sequence of p120 RasGAP coupled with a cell-permeable TAT-derived peptide, sensitizes the death response of various tumor cells to several anticancer treatments. We now report that this peptide is also able to increase cell adherence, prevent cell migration and inhibit matrix invasion. This is accompanied by a marked...

Université de Fribourg

Fragment N2, a caspase-3-generated RasGAP fragment, inhibits breast cancer metastatic progression

Barras, David ; Lorusso, Girieca ; Lhermitte, Benoît ; Viertl, David ; Rüegg, Curzio ; Widmann, Christian

In: International Journal of Cancer, 2014, p. -

The p120 RasGAP protein negatively regulates Ras via its GAP domain. RasGAP carries several other domains that modulate several signaling molecules such as Rho. RasGAP is also a caspase-3 substrate. One of the caspase-3-generated RasGAP fragments, corresponding to amino acids 158–455 and called fragment N2, was previously reported to specifically sensitize cancer cells to death induced by...

Université de Fribourg

Obesity promotes the expansion of metastasis-initiating cells in breast cancer

Bousquenaud, Mélanie ; Fico, Flavia ; Solinas, Giovanni ; Rüegg, Curzio ; Santamaria-Martínez, Albert

In: Breast Cancer Research, 2018, vol. 20, no. 1, p. 104

Obesity is a strong predictor of poor prognosis in breast cancer, especially in postmenopausal women. In particular, tumors in obese patients tend to seed more distant metastases, although the biology behind this observation remains poorly understood.Methods: To elucidate the effects of the obese microenvironment on metastatic spread, we ovariectomized C57BL/6 J female mice and fed them...

Université de Fribourg

PI3Kγ activity in leukocytes promotes adipose tissue inflammation and early-onset insulin resistance during obesity

Breasson, Ludovic ; Becattini, Barbara ; Sardi, Claudia ; Molinaro, Angela ; Zani, Fabio ; Marone, Romina ; Botindari, Fabrizio ; Bousquenaud, Mélanie ; Rüegg, Curzio ; Wymann, Matthias P. ; Solinas, Giovanni

In: Science Signaling, 2017, vol. 10, no. 488, p. eaaf2969

The phosphoinositide 3-kinase γ (PI3Kγ) plays a major role in leukocyte recruitment during acute inflammation and has been proposed to inhibit classical macrophage activation by driving immunosuppressive gene expression. PI3Kγ plays an important role in diet-induced obesity and insulin resistance. In seeking to determine the underlying molecular mechanisms, we showed that PI3Kγ action in...

Université de Fribourg

68Ga-NODAGA-RGDyK for αvβ3 integrin PET imaging : Preclinical investigation and dosimetry

Buchegger, F. ; Viertl, D. ; Baechler, Sébastien ; Dunet, V. ; Kosinski, M. ; Poitry-Yamate, C. ; Rüegg, Curzio ; Prior, J. O.

In: Nuklearmedizin, 2011, vol. 50, no. 6, p. 221-246

Aim: To visualize neovasculature and/or tumour integrin αvβ3 we selected the binding moiety Arg-Gly-Asp-D-Tyr-Lys (RGDyK) coupled to NODAGA for labeling with 68Ga. Methods: NODAGA-RGDyK (ABX) was labeled with the 68Ga eluate from the 68Ge generator IGG100 using the processor unit PharmTracer. Biodistribution was measured in female Hsd mice sacrificed 10, 30, 60 and 90 min after i.v. injection...

Université de Fribourg

Not just fundamental research: education, equal opportunities, knowledge and technology transfer, and communication at the nccr bio-inspired materials

Capper, Scott ; Haskal, Eliav ; Kilbinger, Andreas ; Montero de Espinosa, Lucas ; Rothen-Rutishauser, Barbara ; Rüegg, Curzio ; Weder, Christoph

In: CHIMIA International Journal for Chemistry, 2019, vol. 73, no. 1, p. 86–89

Besides conducting excellent fundamental research in domains of strategic importance, the National Centers of Competence in Research (NCCRs) also aim to become centers of reference for education, equal opportunities, and knowledge and technology transfer. These activities are supported by a communication strategy focused on specific target groups. This article describes some of the main...

Université de Fribourg

MFG-E8/lactadherin regulates cyclins D1/D3 expression and enhances the tumorigenic potential of mammary epithelial cells

Carrascosa, C. ; Obula, R. G. ; Missiaglia, E. ; Lehr, H.-A. ; Delorenzi, M. ; Frattini, M. ; Rüegg, Curzio ; Mariotti, Agnese

In: Oncogene, 2011, p. -

Milk fat globule-EGF factor 8 (MFG-E8) is a glycoprotein highly expressed in breast cancer that contributes to tumor progression through largely undefined mechanisms. By analyzing publicly available gene expression profiles of breast carcinomas, we found that MFG-E8 is highly expressed in primary and metastatic breast carcinomas, associated with absent estrogen receptor expression....