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Università della Svizzera italiana

Neuroticism and internet addiction : What is next? A systematic conceptual review

Marciano, Laura ; Camerini, Anne-Linda ; Schulz, Peter J.

In: Personality and individual differences, 2022, vol. 185, p. 10

The personality trait of neuroticism (N) has consistently shown to be a risk factor for Internet Addiction (IA). Review literature, however, looked at this in bivariate analyses only. To the best of our knowledge, we conducted the first review that systematically and conceptually summarized results based on the inclusion of additional factors, thus coming closer to the complex nature of the ...

Università della Svizzera italiana

Recommendations on screen time, sleep and physical activity : associations with academic achievement in Swiss adolescents

Marciano, Laura ; Camerini, Anne-Linda

In: Public health, 2021, vol. 198, p. 211-217

Objectives: This study aimed to investigate how meeting international recommendations for screen time (<2 h/day), moderate-to-vigorous physical activity (MVPA; at least 60 min/day) and sleep (8e10 h/night), as well as media multitasking (MMI) as a form of screen time, impact academic achievement in early adolescence. Study design: A prospective design was used, where self-report measures...

Università della Svizzera italiana

How smartphone use becomes problematic : application of the ALT-SR model to study the predicting role of personality traits

Marciano, Laura ; Schulz, Peter Johannes ; Camerini, Anne-Linda

In: Computers in human behavior, 2021, vol. 119, no. June, p. 14 p

Smartphones have become a ubiquitous part of adolescents' life, and studies have repeatedly revealed a positive association between smartphone use (SU) and problematic smartphone use (PSU). However, longitudinal research investigating the reciprocal relationship among SU and PSU during adolescence are scarce, and studies that take into consideration personality traits as predisposing factors...

Università della Svizzera italiana

Neuroticism in the digital age : a meta-analysis

Marciano, Laura ; Camerini, Anne-Linda ; Schulz, Peter J.

In: Computers in human behavior reports, 2020, vol. 2, no. August–December, p. 14 p

The pervasiveness of the Internet has raised concern about its (problematic) use and the potentially negative impact on people's health. Neuroticism has been identified as one potential risk factor of Internet and other online addictions. To obtain a comprehensive quantitative synthesis of the association of neuroticism and both overall and problematic Internet activities, a meta-analysis was...

Università della Svizzera italiana

Disentangling individual phases in the hunted vs. farmed meat supply chain : exploring hunters’ perceptions in Italy

Marescotti, Maria Elena ; Demartini, Eugenio ; Gibbert, Michael ; Viganò, Roberto ; Gaviglio, Anna

In: Foods, 2021, vol. 10, no. 1, p. 15 p

The growing body of literature concerning the hunted wild game meat (HWGM) supply chain is mainly focused on the final consumer, while little is known about upstream production processes. Even though the hunter plays a central role here, it is not well understood how hunters themselves perceive their role in the various phases of the production process. The present study explores Italian...

Università della Svizzera italiana

Human IFN-γ immunity to mycobacteria is governed by both IL-12 and IL-23

Markle, Janet G. ; Martínez-Barricarte, Rubén ; Ma, Cindy S. ; Deenick, Elissa K. ; Ramírez-Alejo, Noé ; Mele, Federico ; Latorre, Daniela ; Mahdaviani, Seyed Alireza ; Aytekin, Caner ; Mansouri, Davood ; Bryant, Vanessa L. ; Jabot-Hanin, Fabienne ; Deswarte, Caroline ; Nieto-Patlán, Alejandro ; Surace, Laura ; Kerner, Gaspard ; Itan, Yuval ; Jovic, Sandra ; Avery, Danielle T. ; Wong, Natalie ; Rao, Geetha ; Patin, Etienne ; Okada, Satoshi ; Bigio, Benedetta ; Boisson, Bertrand ; Rapaport, Franck ; Seeleuthner, Yoann ; Schmidt, Monika ; Ikinciogullari, Aydan ; Dogu, Figen ; Tanir, Gonul ; Tabarsi, Payam ; Bloursaz, Mohammed Reza ; Joseph, Julia K. ; Heer, Avneet ; Kong, Xiao-Fei ; Migaud, Mélanie ; Lazarov, Tomi ; Geissmann, Frédéric ; Fleckenstein, Bernhard ; Lindestam Arlehamn, Cecilia ; Sette, Alessandro ; Puel, Anne ; Emile, Jean-François ; Vosse, Esther van de ; Quintana-Murci, Lluis ; Di Santo, James P. ; Abel, Laurent ; Boisson-Dupuis, Stéphanie ; Bustamante, Jacinta ; Tangye, Stuart G. ; Sallusto, Federica ; Casanova, Jean-Laurent

In: Science Immunology, 2018, vol. 3, no. 30, p. eaau6759

Hundreds of patients with autosomal recessive, complete IL-12p40 or IL-12Rß1 deficiency have been diagnosed over the last 20 years. They typically suffer from invasive mycobacteriosis and, occasionally, from mucocutaneous candidiasis. Susceptibility to these infections is thought to be due to impairments of IL- 12–dependent IFN-? immunity and IL-23–dependent IL-17A/IL-17F immunity,...

Università della Svizzera italiana

Rag defects and thymic stroma : lessons from animal models

Marrella, Veronica ; Poliani, Pietro Luigi ; Notarangelo, Luigi Daniele ; Grassi, Fabio ; Villa, Anna

In: Frontiers in immunology, 2014, vol. 5, p. 259

Thymocytes and thymic epithelial cells (TECs) cross-talk is essential to support T cell development and preserve thymic architecture and maturation of TECs and Foxp3+ natural regulatory T cells. Accordingly, disruption of thymic lymphostromal cross-talk may have major implications on the thymic mechanisms that govern T cell tolerance. Several genetic defects have been described in humans that...

Università della Svizzera italiana

Herpes simplex virus enhances chemokine function through modulation of receptor trafficking and oligomerization

Martinez-Martin, Nadia ; Viejo-Borbolla, Abel ; Martín, Rocío ; Soledad, Blanco ; Benovic, Jeffrey L. ; Thelen, Marcus ; Alcamí, Antonio

In: Nature communications, 2015, vol. 6, p. 6163

Glycoprotein G (gG) from herpes simplex virus 1 and 2 (HSV-1 and HSV-2, important human neurotropic pathogens) is the first viral chemokine-binding protein found to potentiate chemokine function. Here we show that gG attaches to cell surface glycosaminoglycans and induces lipid raft clustering, increasing the incorporation of CXCR4 receptors into these microdomains. gG induces conformational...

Università della Svizzera italiana

Crisi dei subprimes : Quali insegnamenti per gli enti pubblici locali francesi

Marty, Frédéric ; Gianella, Tobiolo

In: Rivista italiana di ragioneria e di economia aziendale, 2008, vol. CVIII, no. 9-10, p. 631-637

Università della Svizzera italiana

Multi-targeting bioactive compounds extracted from essential oils as kinase inhibitors

Maruca, Annalisa ; Lanzillotta, Delia ; Rocca, Roberta ; Lupia, Antonio ; Costa, Giosuè ; Catalano, Raffaella ; Moraca, Federica ; Gaudio, Eugenio ; Ortuso, Francesco ; Artese, Anna ; Trapasso, Francesco ; Alcaro, Stefano

In: Molecules, 2020, vol. 25, no. 9, p. 14 p

Essential oils (EOs) are popular in aromatherapy, a branch of alternative medicine that claims their curative effects. Moreover, several studies reported EOs as potential anti- cancer agents by inducing apoptosis in different cancer cell models. In this study, we have considered EOs as a potential resource of new kinase inhibitors with a polypharmacological profile. On the other hand,...