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Université de Fribourg

Jasmonate-induced plant defenses and prey availability impact the preference and performance of an omnivorous stink bug, Podisus maculiventris

Thaler, Jennifer S. ; Olsen, Elena L. ; Kaplan, Ian

In: Arthropod-Plant Interactions, 2015, p. 1–8

Many omnivorous insects are important biological control agents, and their success is influenced by both plant resistance and prey availability. The potential impact of these two factors is complicated by the fact that they may not be independent: Resistant plants also often support fewer herbivorous prey. We studied how lifetime development, growth, fecundity and preference of the omnivorous...

Université de Fribourg

Areas of high conservation value in Georgia: present and future threats by invasive alien plants

Thalmann, Daniela Julia Klara ; Kikodze, David ; Khutsishvili, Manana ; Kharazishvili, David ; Guisan, Antoine ; Broennimann, Olivier ; Müller-Schärer, Heinz

In: Biological Invasions, 2015, vol. 17, no. 4, p. 1041–1054

Georgia is known for its extraordinary rich biodiversity of plants, which may now be threatened due to the spread of invasive alien plants (IAP). We aimed to identify (1) the most prominent IAP out of 9 selected potentially invasive and harmful IAP by predicting their distribution under current and future climate conditions in Georgia as well as in its 43 Protected Areas, as a proxy for areas of...

Université de Fribourg

Historical sampling reveals dramatic demographic changes in western gorilla populations

Thalmann, Olaf ; Wegmann, Daniel ; Spitzner, Marie ; Arandjelovic, Mimi ; Guschanski, Katerina ; Leuenberger, Christoph ; Bergl, Richard A ; Vigilant, Linda

In: BMC Evolutionary Biology, 2011, vol. 11, p. 85

Background: Today many large mammals live in small, fragmented populations, but it is often unclear whether this subdivision is the result of long-term or recent events. Demographic modeling using genetic data can estimate changes in long-term population sizes while temporal sampling provides a way to compare genetic variation present today with that sampled in the past. In order to better...

Université de Fribourg

Development of resiquimod-loaded modified PLA-based nanoparticles for cancer immunotherapy: A kinetic study

Thauvin, Cédric ; Widmer, Jérôme ; Mottas, Inès ; Hocevar, Sandra ; Allémann, Eric ; Bourquin, Carole ; Delie, Florence

In: European Journal of Pharmaceutics and Biopharmaceutics, 2019, vol. 139, p. 253–261

Resiquimod (R848), a member of the imidazoquinoline family, is a Toll-like receptor 7/8 agonist with high potency for cancer immunotherapy. However, tolerance induction and adverse effects limit its development as a drug. Encapsulation in a polymer matrix can circumvent these limitations, as shown in our formerly published approach where R848 was loaded into polylactic acid (PLA)-based...

Université de Fribourg

Polyploidy and invasion success: trait trade-offs in native and introduced cytotypes of two Asteraceae species

Thébault, Aurélie ; Gillet, François ; Müller-Schärer, Heinz ; Buttler, Alexandre

In: Plant Ecology, 2010, vol. 212, no. 2, p. 315-325

Invasion success is favoured by the introduction of pre-adapted genotypes. In addition, novel pressures in the introduced range may lead to phenotypic changes related to fitness or competitive ability of introduced plants. Polyploidy appears to be over-represented in invasive plants, but differences between cytotypes in growth strategies including trade-offs among plant traits have received...

Université de Fribourg

ANP-induced signalling cascade and its implications in renal pathophysiology

Theilig, Franziska ; Wu, Qinyu

In: American Journal of Physiology - Renal Physiology, 2015, p. -

The balance between vasoconstrictor/sodium retaining and vasodilator/natriuretic systems is essential for maintaining body fluid and electrolyte homeostasis. Natriuretic peptides, such as atrial natriuretic protein (ANP) belong to the vasodilator/natriuretic system. ANP is produced by the conversion of pro-ANP into ANP which is achieved by a proteolytical cleavage executed by corin. In the...

Université de Fribourg

Tubular deficiency of von Hippel-Lindau attenuates renal disease progression in anti-GBM glomerulonephritis

Theilig, Franziska ; Enke, Anne Kathrin ; Scolari, Brigitte ; Polzin, Danny ; Bachmann, Sebastian ; Koesters, Robert

In: The American Journal of Pathology, 2011, vol. 179, no. 5, p. 2177–2188

In many kidney diseases, the original insult primarily involves the glomerulus and may then pass onto the tubulointerstitium. Several hypotheses link glomerular disease to tubular injury; perhaps the foremost hypothesis involves chronic tubular hypoxia. The reported effects of hypoxia and consecutive stabilization of hypoxia-inducible factors (HIFs), however, are controversial. Hypoxia induces...