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Université de Fribourg

RTerseaanrchs acrtricileptome analysis reveals a major impact of JAK protein tyrosine kinase 2 (Tyk2) on the expression of interferon-responsive and metabolic genes

Vogl, Claus ; Flatt, Thomas ; Fuhrmann, Bernd ; Hofmann, Elisabeth ; Wallner, Barbara ; Stiefvater, Rita ; Kovarik, Pavel ; Strobl, Birgit ; Müller, Mathias

In: BMC Genomics, 2010, vol. 11, no. 199, p. 1-19

Background: Tyrosine kinase 2 (Tyk2), a central component of Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling, has major effects on innate immunity and inflammation. Mice lacking Tyk2 are resistant to endotoxin shock induced by lipopolysaccharide (LPS), and Tyk2 deficient macrophages fail to efficiently induce interferon alpha/beta after LPS treatment. However,...

Université de Fribourg

Host range and Specificity of the Drosophila C Virus

Kapun, Martin ; Nolte, Viola ; Flatt, Thomas ; Schlötterer, Christian

In: PLoS ONE, 2010, vol. 5, no. 8, p. 1-5

Background: The Drosophila C virus (DCV) is a common and well-studied Drosophila pathogen. Although natural infections are known from Drosophila melanogaster and D. simulans, and artificial infections have been reported from several. Drosophila species and other insects, it remains unclear to date whether DCV infections also occur naturally in other Drosophila species. Methods/Principal Findings:...

Université de Fribourg

Dietary restriction and other lifespan extending pathways converge at the activation of the downstream effector takeout.

Gáliková, Martina

In: Aging, 2010, vol. 2, no. 7, p. 387-389

Dietary restriction (DR), reduced food uptake without malnutrition, is the most universal intervention known to extend animal lifespan, from invertebrates to mammals [1]. However, despite impressive progress in identifying the key components of the DR pathway, many proximal effectors of DR induced longevity remain unknown to date [1]. One central obstacle in the search for such mechanisms is that...

Université de Fribourg

Aging and Its Demographic Measurement

Bronikowski, Anne M. ; Flatt, Thomas

In: Nature Education Knowledge, 2010, vol. 1, no. 12, p. 1-6

This case study highlights the general issues raised earlier. First, that maximum lifespan is not an easily obtainable metric. Specifically, it is unambiguous in the sense that once the last animal dies, it is most definitely dead. But to estimate the variance in maximum lifespan, many replicate populations would need to be followed for each treatment group (with each replicate providing a single...

Université de Fribourg

Progressive signaling changes in the olfactory nerve of patients with Alzheimer’s disease

Bathini, Praveen ; Mottas, Antoine ; Jaquet, Muriel ; Brai, Emanuele ; Alberi, Lavinia

In: Neurobiology of Aging, 2019, vol. 76, p. 80–95

Olfaction declines with aging and appears to be a prodromal sign of cognitive decline in progressive neurodegenerative diseases. Nevertheless, very little is known about the pathophysiological changes underlying smell loss that may reflect early network dysfunction. A cross-sectional histoanatomical study was conducted on postmortem olfactory nerves of patients with increasing severity of...

Université de Neuchâtel

Statistical metrics for the characterization of karst network geometry and topology

Collon, P ; Bernasconi, D ; Vuilleumier, C ; Renard, Philippe

In: Geomorphology, 2017, vol. 283, p. 122-142

Statistical metrics can be used to analyse the morphology of natural or simulated karst systems; they allow describing, comparing, and quantifying their geometry and topology. In this paper, we present and discuss a set of such metrics. We study their properties and their usefulness based on a set of more than 30 karstic networks mapped by speleologists. The data set includes some of the largest...

Université de Fribourg

Diet and longevity in the balance

Flatt, Thomas

In: Nature, 2009, vol. 462, no. 24, p. 989-990

Dietary restriction promotes longevity but impairs fecundity in many organisms. When the amino acids in a diet are fine-tuned, however, lifespan can be increased without loss of fecundity — at least in fruitflies.

Université de Fribourg

A new testudinoid turtle from the middle to late Eocene of Vietnam

Garbin, Rafaella C. ; Böhme, Madelaine ; Joyce, Walter G.

In: PeerJ, 2019, vol. 7, p. e6280

Testudinoidea is a major clade of turtles that has colonized different ecological environments across the globe throughout the Tertiary. Aquatic testudinoids have a particularly rich fossil record in the Tertiary of the northern hemisphere, but little is known about the evolutionary history of the group, as the phylogenetic relationships of most fossils have not been established with...

Université de Fribourg

Change detection of bare-ice albedo in the Swiss Alps

Naegeli, Kathrin ; Huss, Matthias ; Hoelzle, Martin

In: The Cryosphere, 2019, vol. 13, no. 1, p. 397–412

Albedo feedback is an important driver of glacier melt over bare-ice surfaces. Light- absorbing impurities strongly enhance glacier melt rates but their abundance, composition and variations in space and time are subject to considerable uncertainties and ongoing scientific debates. In this study, we assess the temporal evolution of shortwave broadband albedo derived from 15 end-of-summer...

Université de Neuchâtel

On the use of multiple-point statistics to improve groundwater flow modeling in karst aquifers : A case study from the Hydrogeological Experimental Site of Poitiers, France

Le Coz, M ; Bodin, J ; Renard, Philippe

In: Journal of Hydrology, 2017, vol. 545, p. 109-119

Limestone aquifers often exhibit complex groundwater flow behaviors resulting from depositional heterogeneities and post-lithification fracturing and karstification. In this study, multiple-point statistics (MPS) was applied to reproduce karst features and to improve groundwater flow modeling. For this purpose, MPS realizations were used in a numerical flow model to simulate the responses to...