In: Circulation, 2010, vol. 121, p. 123-131
Background— Endothelial dysfunction is the initiating event of atherosclerosis. The expression of connexin40 (Cx40), an endothelial gap junction protein, is decreased during atherogenesis. In the present report, we sought to determine whether Cx40 contributes to the development of the disease.Methods and Results— Mice with ubiquitous deletion of Cx40 are hypertensive, a risk factor for...
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In: Neuroscience, 2010, vol. 165, no. 3, p. 749-757
The calcium-binding proteins parvalbumin, calbindin D-28k, calretinin and calcineurin are present in subsets of GABAergic gigantic calyciform presynaptic terminals of the reticular thalamic nucleus (RTN). Previously it was hypothesized that GABA and calcium-binding proteins including parvalbumin are not only colocalized in the same neuron subpopulation, but that GABA synthesis and parvalbumin...
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In: Journal of Neurophysiology, 2010, vol. 103, p. 371-381
Cav2.1 channels regulate Ca²⁺ signaling and excitability of cerebellar Purkinje neurons. These channels undergo a dual feedback regulation by incoming Ca²⁺ ions, Ca²⁺-dependent facilitation and inactivation. Endogenous Ca²⁺-buffering proteins, such as parvalbumin (PV) and calbindin D-28k (CB), are highly expressed in Purkinje neurons and therefore may influence...
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In: Journal of Cell Science, 2010, vol. 123, p. 141-151
Cells of Saccharomyces cerevisiae lacking Apq12, a nuclear envelope (NE)-endoplasmic reticulum (ER) integral membrane protein, are defective in assembly of nuclear pore complexes (NPCs), possibly because of defects in regulating membrane fluidity. We identified BRR6, which encodes an essential integral membrane protein of the NE-ER, as a dosage suppressor of apq12δ. Cells...
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In: BMC Neuroscience, 2009, vol. 10, p. 155
Background Polymicrogyria is a malformation of the cerebral cortex often resulting in epilepsy or mental retardation. It remains unclear whether this pathology affects the structure and function of the corticospinal (CS) system. The anatomy and histology of the brain of one macaque monkey exhibiting a spontaneous polymicrogyria (PMG monkey) were examined and compared to the brain of normal...
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In: Journal of Neurophysiology, 2010, p. -
Manual dexterity, a prerogative of primates, is under the control of the corticospinal (CS) tract. As 90-95% of CS axons decussate, it is assumed that this control is exerted essentially on the contralateral hand. Consistently, unilateral lesion of the hand representation in the motor cortex is followed by a complete loss of dexterity of the contralesional hand. During the months following...
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In: International Journal of Psychophysiology, 2010, vol. 75, no. 1, p. 48-53
Cardiovascular responses to single stressors diminish over time. Interaction of different stressors influencing hemodynamic variables, indicative of stress-induced reactivity and physiological responses are, however, poorly understood. We investigated time course of mental (using mental arithmetic, MA) and orthostatic (using head up tilt, HUT) challenges induced responses in 16 males. Three...
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In: International Journal of Psychophysiology, 2010, vol. 75, no. 1, p. 54-62
Post stress neurovascular responses induced by physical and mental stress are poorly understood. We investigated the time course of cardiovascular and autonomic recovery, induced by orthostatic and mental challenge, using passive head up tilt (HUT) and mental arithmetic (MA), respectively, when applied singly (MA, HUT) or in combination (MA + HUT). Fifteen healthy males participated in three...
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In: American Journal of Physiology Regulatory, Integrative and Comparative Physiolology, 2010, p. -
Alterations in the circadian blood pressure pattern are frequently observed in hypertension and lead to increased cardiovascular morbidity. However, there are no studies that have investigated a possible implication of the Period2 gene, a key component of the molecular circadian clock, on the circadian rhythms of blood pressure and heart rate. To address this question, we monitored blood...
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In: Acta Astronautica, 2010, p. -
We assessed hemodynamic responses induced by orthostatic and mental stressors, using passive head up tilt (HUT) and mental arithmetic (MA), respectively. The 15 healthy males underwent three protocols: (1) HUT alone, (2) MA in supine position and (3) MA+HUT, with sessions randomized and ≥2 weeks apart. In relation to baseline, HUT increased heart rate (HR) (+20.4±7.1 bpm; p<0.001),...
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