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Parola chiave

Université de Fribourg

Lentiviral vector-mediated dopamine D3 receptor modulation in the rat brain impairs alcohol intake and ethanol-induced conditioned place preference

Bahi, Amine ; Dreyer, Jean-Luc

In: Alcoholism: Clinical and Experimental Research, 2014, vol. 38, no. 9, p. 2369–2376

Background: It has been reported that dopamine D3 receptor (D3R) knockout mice display similar ethanol (EtOH) consumption compared to wild types. In addition, studies with D3R pharmacological targeting were inconclusive.Methods: In the current study, we used both gain- and loss-of-function approaches to test the effects of central D3R manipulation on voluntary alcohol intake and EtOH-induced...