Université de Fribourg

The FKBP4 gene, encoding a regulator of the androgen receptor signaling pathway, is a novel candidate gene for androgen insensitivity syndrome

Ilaslan, Erkut ; Markosyan, Renata ; Sproll, Patrick ; Stevenson, Brian J. ; Sajek, Malgorzata ; Sajek, Marcin P. ; Hayrapetyan, Hasmik ; Sarkisian, Tamara ; Livshits, Ludmila ; Nef, Serge ; Jaruzelska, Jadwiga ; Kusz-Zamelczyk, Kamila

In: International Journal of Molecular Sciences, 2020, vol. 21, no. 21, p. 8403

Androgen insensitivity syndrome (AIS), manifesting incomplete virilization in 46,XY individuals, is caused mostly by androgen receptor (AR) gene mutations. Therefore, a search for AR mutations is a routine approach in AIS diagnosis. However, some AIS patients lack AR mutations, which complicates the diagnosis. Here, we describe a patient suffering from partial androgen insensitivity syndrome...

Université de Fribourg

Angiogenic activity of breast cancer patients’ monocytes reverted by combined use of systems modeling and experimental approaches

Guex, Nicolas ; Crespo, Isaac ; Bron, Sylvian ; Ifticene-Treboux, Assia ; Faes-van’t Hull, Eveline ; Kharoubi, Solange ; Liechti, Robin ; Werffeli, Patricia ; Ibberson, Mark ; Majo, Francois ; Nicolas, Michäel ; Laurent, Julien ; Garg, Abhishek ; Lehr, Khalil Zaman,Hans-Anton ; Stevenson, Brian J. ; Rüegg, Curzio ; Coukos, George ; Delaloye, Jean-François ; Xenarios, Ioannis ; Doucey, Marie-Agnès

In: PLoS Comput Biol, 2015, vol. 11, no. 3, p. e1004050

Angiogenesis plays a key role in tumor growth and cancer progression. TIE-2-expressing monocytes (TEM) have been reported to critically account for tumor vascularization and growth in mouse tumor experimental models, but the molecular basis of their pro-angiogenic activity are largely unknown. Moreover, differences in the pro-angiogenic activity between blood circulating and tumor infiltrated TEM...