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Kinase signalling pathways in endometriosis: potential targets for non-hormonal therapeutics

McKinnon, Brett D. ; Kocbek, Vida ; Nirgianakis, Kostantinos ; Bersinger, Nick A. ; Mueller, Michael D.

In: Human Reproduction Update, 2016, vol. 22, no. 3, p. 382-403

mTOR in health and in sickness

Liko, Dritan ; Hall, Michael

In: Journal of Molecular Medicine, 2015, vol. 93, no. 10, p. 1061-1073

The mTOR Pathway in Breast Cancer

Hynes, Nancy ; Boulay, Anne

In: Journal of Mammary Gland Biology and Neoplasia, 2006, vol. 11, no. 1, p. 53-61

Small molecules and targeted therapies in distant metastatic disease

Hersey, P.

In: Annals of Oncology, 2009, vol. 20, p. vi35-vi40

Inhibition of mTOR with sirolimus slows disease progression in Han:SPRD rats with autosomal dominant polycystic kidney disease (ADPKD)

Wahl, Patricia R. ; Serra, Andreas L. ; Le Hir, Michel ; Molle, Klaus D. ; Hall, Michael N. ; Wüthrich, Rudolf P.

In: Nephrology Dialysis Transplantation, 2006, vol. 21, no. 3, p. 598-604

Antagonism of the mammalian target of rapamycin selectively mediates metabolic effects of epidermal growth factor receptor inhibition and protects human malignant glioma cells from hypoxia-induced cell death

Ronellenfitsch, Michael W. ; Brucker, Daniel P. ; Burger, Michael C. ; Wolking, Stefan ; Tritschler, Felix ; Rieger, Johannes ; Wick, Wolfgang ; Weller, Michael ; Steinbach, Joachim P.

In: Brain, 2009, vol. 132, no. 6, p. 1509-1522

mTOR signalling: the molecular interface connecting metabolic stress, aging and cardiovascular diseases

Yang, Zhihong ; Ming, Xiu-Fen

In: Obesity Reviews, 2012, vol. 13, no. S2, p. 58–68

The continuing increase in the prevalence of obesity and metabolic disorders such as type-II diabetes and an accelerating aging population globally will remain the major contributors to cardiovascular mortality and morbidity in the 21st century. It is well known that aging is highly associated with metabolic and cardiovascular diseases. Growing evidence also shows that obesity and metabolic...

Perspectives of targeting mTORC1–S6K1 in cardiovascular aging

Ming, Xiu-Fen ; Montani, Jean-Pierre ; Yang, Zhihong

In: Frontiers in Vascular Physiology, 2012, vol. 3, p. 5

The global population aging is accelerating and age-associated diseases including cardiovascular diseases become more challenging. The underlying mechanisms of aging and age-associated cardiovascular dysfunction remain elusive. There are substantial evidences demonstrating a pivotal role of the mammalian target of rapamycin complex 1 (mTORC1) and its down-stream effector S6K1 signaling in...

Opposing and uncoupling effects of mTOR and S6K1 in the regulation of endothelial tissue factor expression

Ming, Xiu-Fen ; Rajapakse, Angana Gupta ; Carvas, João Miguel ; Ruffieux, Jean ; Yang, Zhihong

In: Febs Letters, 2010, vol. 58, no. 1, p. 135-140

Rapamycin has been reported to enhance tissue factor (TF) expression. The present study investigated roles of mammalian target of rapamycin (mTOR) and its downstream S6K1 in this process. We showed here that, consistent with rapamycin, knocking-down mTOR enhanced thrombin-induced TF mRNA and protein levels, whereas silencing S6K1 mitigated up-regulation of TF protein but not TF mRNA level. The...