Université de Fribourg

A role for adipose tissue de novo lipogenesis in glucose homeostasis during catch-up growth : a randle cycle favoring fat storage

Marcelino, Helena ; Veyrat-Durebex, Christelle ; Summermatter, Serge ; Sarafian, Delphine ; Miles-Chan, Jennifer ; Arsenijevic, Denis ; Zani, Fabio ; Montani, Jean-Pierre ; Seydoux, Josiane ; Solinas, Giovanni ; Rohner-Jeanrenaud, Françoise ; Dulloo, Abdul G.

In: Diabetes, 2013, vol. 62, no. 2, p. 362-372

Catch-up growth, a risk factor for type 2 diabetes, is characterized by hyperinsulinemia and accelerated body fat recovery. Using a rat model of semistarvation-refeeding that exhibits catch-up fat, we previously reported that during refeeding on a low-fat diet, glucose tolerance is normal but insulin-dependent glucose utilization is decreased in skeletal muscle and increased in adipose tissue,...

Université de Fribourg

High identification rates of endogenous neuropeptides from mouse brain

Zhang, Xiaozhe ; Petruzziello, Filomena ; Zani, Fabio ; Fouillen, Laetitia ; Andren, Per E. ; Solinas, Giovanni ; Rainer, Gregor

In: Journal of Proteome Research, 2012, vol. 11, no. 5, p. 2819–2827

Mass spectrometry-based neuropeptidomics is one of the most powerful approaches for identification of endogenous neuropeptides in the brain. Until now, however, the identification rate of neuropeptides in neuropeptidomics is relatively low and this severely restricts insights into their biological function. In the present study, we developed a high accuracy mass spectrometry-based approach to...

Université de Fribourg

PI3Kγ within a nonhematopoietic cell type negatively regulates diet-induced thermogenesis and promotes obesity and insulin resistance

Becattini, Barbara ; Marone, Romina ; Zani, Fabio ; Arsenijevic, Denis ; Seydoux, Josiane ; Montani, Jean-Pierre ; Dulloo, Abdul G. ; Thorens, Bernard ; Preitner, Frédéric ; Wymann, Matthias P. ; Solinas, Giovanni

In: Proceedings of the National Academy of Sciences of the United States of America, 2011, vol. 108, no. 42, p. E854-E863

Obesity is associated with a chronic low-grade inflammation, and specific antiinflammatory interventions may be beneficial for the treatment of type 2 diabetes and other obesity-related diseases. The lipid kinase PI3Kγ is a central proinflammatory signal transducer that plays a major role in leukocyte chemotaxis, mast cell degranulation, and endothelial cell activation. It was also reported that...

Université de Fribourg

Loss of the actin remodeler Eps8 causes intestinal defects and improved metabolic status in mice

Tocchetti, Arianna ; Soppo, Charlotte Blanche Ekalle ; Zani, Fabio ; Bianchi, Fabrizio ; Gagliani, Maria Cristina ; Pozzi, Benedetta ; Rozman, Jan ; Elvert, Ralf ; Ehrhardt, Nicole ; Rathkolb, Birgit ; Moerth, Corinna ; Horsch, Marion ; Fuchs, Helmut ; Gailus-Durner, Valérie ; Beckers, Johannes ; Klingenspor, Martin ; Wolf, Eckhard ; Hrabé de Angelis, Martin ; Scanziani, Eugenio ; Tacchetti, Carlo ; Scita, Giorgio ; Di Fiore, Pier Paolo ; Offenhäuser, Nina

In: PLoS ONE, 2010, vol. 5, no. 3, p. e9468

Background: In a variety of organisms, including mammals, caloric restriction improves metabolic status and lowers the incidence of chronic-degenerative diseases, ultimately leading to increased lifespan. Methodology/Principal Findings: Here we show that knockout mice for Eps8, a regulator of actin dynamics, display reduced body weight, partial resistance to age- or diet-induced obesity, and...