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Université de Fribourg

Single exposure to aerosolized graphene oxide and graphene nanoplatelets did not initiate an acute biological response in a 3D human lung model

Drasler, Barbara ; Kucki, Melanie ; Delhaes, Flavien ; Buerki-Thurnherr, Tina ; Vanhecke, Dimitri ; Korejwo, Daria ; Chortare, Savvina ; Barosova, Hana ; Hirsch, Cordula ; Petri-Fink, Alke ; Rothen-Rutishauser, Barbara ; Wick, Peter

In: Carbon, 2018, vol. 137, p. 125–135

The increased mass production of graphene related materials (GRM), intended for a broad spectrum of applications, demands a thorough assessment of their potential hazard to humans and the environment. Particularly, the paramount concern has been expressed in regard to their interaction with the respiratory system in occupational exposure settings. It has been shown that GRM are easily...

Consortium of Swiss Academic Libraries

Single walled carbon nanotubes (SWCNT) affect cell physiology and cell architecture

Kaiser, Jean-Pierre ; Wick, Peter ; Manser, Pius ; Spohn, Philipp ; Bruinink, Arie

In: Journal of Materials Science: Materials in Medicine, 2008, vol. 19, no. 4, p. 1523-1527

Université de Fribourg

Human asthmatic bronchial cells are more susceptible to subchronic repeated exposures of aerosolized carbon nanotubes at occupationally relevant doses than healthy cells

Chortarea, Savvina ; Barosova, Hana ; Clift, Martin James David ; Wick, Peter ; Petri-Fink, Alke ; Rothen-Rutishauser, Barbara

In: ACS Nano, 2017, p. -

Although acute pulmonary toxicity of carbon nanotubes (CNTs) has been extensively investigated, the knowledge of potential health effects following chronic occupational exposure is currently limited and based only upon in vivo approaches. Our aim was to realistically mimic subchronic inhalation of multiwalled CNTs (MWCNTs) in vitro, using the air–liquid interface cell exposure (ALICE)...

Université de Fribourg

A comparative study of different in vitro lung cell culture systems to assess the most beneficial tool for screening the potential adverse effects of carbon nanotubes

Clift, Martin J. D. ; Endes, Carola ; Vanhecke, Dimitri ; Wick, Peter ; Gehr, Peter ; Schins, Roel P. F. ; Petri-Fink, Alke ; Rothen-Rutishauser, Barbara

In: Toxicological Sciences, 2014, vol. 137, no. 1, p. 55–64

To determine the potential inhalatory risk posed by carbon nanotubes (CNTs), a tier-based approach beginning with an in vitro assessment must be adopted. The purpose of this study therefore was to compare 4 commonly used in vitro systems of the human lung (human blood monocyte-derived macrophages [MDM] and monocyte-derived dendritic cells [MDDC], 16HBE14o- epithelial cells, and...

Université de Fribourg

Can the Ames test provide an insight into nano-object mutagenicity? Investigating the interaction between nano-objects and bacteria

Clift, Martin J. D. ; Raemy, David O. ; Endes, Carola ; Ali, Zulqurnain ; Lehmann, Andrea D. ; Brandenberger, Christina ; Petri-Fink, Alke ; Wick, Peter ; Parak, Wolfgang J. ; Gehr, Peter ; Schins, Roel P. F. ; Rothen-Rutishauser, Barbara

In: Nanotoxicology, 2013, vol. 7, no. 8, p. 1373–1385

The aim of this study was to assess the interaction of a series of well characterised nano-objects with the Gram negative bacterium Salmonella typhimurium, and how such an interaction may relate to the potential mutagenicity of nano-objects. Transmission electron microscopy showed that nano-objects (Au-PMA-ATTO NPs, CeO₂ NPs, SWCNTs and MWCNTs), as well as CAFs entered S....