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Université de Fribourg

Asymmetric and distant effects of a unilateral lesion of the primary motor cortex on the bilateral supplementary motor areas in adult macaque monkeys

Contestabile, Alessandro. ; Colangiulo, R. ; Lucchini, Matteo ; Gindrat, Anne-Dominique ; Hamadjida, Adjia ; Kaeser, Mélanie ; Savidan, Julie ; Wyss, A. F. ; Rouiller, Eric M. ; Schmidlin, Eric

In: Journal of Neuroscience, 2018, vol. 38, no. 50, p. 10644–10656

A restricted lesion of the hand area in the primary motor cortex (M1) leads to a deficit of contralesional manual dexterity, followed by an incomplete functional recovery, accompanied by plastic changes in M1 itself and in other cortical areas on both hemispheres. Using the marker SMI-32 specific to pyramidal neurons in cortical layers III and V, we investigated the impact of a focal...

Université de Fribourg

Birth and death of a phantom

Dieguez, Sebastian ; Kaeser, Mélanie ; Roux, Camille ; Cottet, Jérôme ; Annoni, Jean-Marie ; Schmidlin, Eric

In: Annals of Clinical and Translational Neurology, 2018, vol. 5, no. 1, p. 98–101

Patients with supernumerary phantom limb report experiencing an additional limb duplicating its physical counterpart, usually following a stroke with sensorimotor disturbances. Here, we report a short-lasting case of a right upper supernumerary phantom limb with unusual visuomotor features in a healthy participant during a pure Jacksonian motor seizure unexpectedly induced by continuous...

Université de Fribourg

Role of primary motor cortex in the control of manual dexterity assessed via sequential bilateral lesion in the adult macaque monkey: A case study

Savidan, Julie ; Kaeser, Mélanie ; Belhaj-Saïf, Abderraouf ; Schmidlin, Eric ; Rouiller, Eric

In: Neuroscience, 2017, vol. 357, p. 303–324

From a case study, we describe the impact of unilateral lesion of the hand area in the primary motor cortex (M1) on manual dexterity and the role of the intact contralesional M1 in long-term functional recovery. An adult macaque monkey performed two manual dexterity tasks: (i) “modified Brinkman board” task, assessed simple precision grip versus complex precision grip, the latter involved a...

Université de Fribourg

Effects of dorsolateral prefrontal cortex lesion on motor habit and performance assessed with manual grasping and control of force in macaque monkeys

Badoud, Simon ; Borgognon, Simon ; Cottet, Jérôme ; Chatagny, Pauline ; Moret, Véronique ; Fregosi, Michela ; Kaeser, Mélanie ; Fortis, Ekaterina ; Schmidlin, Eric ; Bloch, Jocelyne ; Brunet, Jean-François ; Rouiller, Eric M.

In: Brain Structure and Function, 2017, vol. 222, no. 3, p. 1193–1206

In the context of an autologous adult neural cell ecosystem (ANCE) transplantation study, four intact adult female macaque monkeys underwent a unilateral biopsy of the dorsolateral prefrontal cortex (dlPFC) to provide the cellular material needed to obtain the ANCE. Monkeys were previously trained to perform quantitative motor (manual dexterity) tasks, namely, the “modified-Brinkman...

Université de Fribourg

Posterior SMA Syndrome following subcortical stroke: Contralateral akinesia reversed by visual feedback

Radman, Narges ; Cacioppo, Stephanie ; Spierer, Lucas ; Schmidlin, Eric ; Mayer, Eugène ; Annoni, Jean-Marie

In: Neuropsychologia, 2013, vol. 51, no. 13, p. 2605–2610

Background: The supplementary motor area (SMA) plays a key role in motor programming and production and is involved in internally-cued movements. In neurological populations, SMA syndrome following a lesion to the “SMA proper” is characterized by transient impairment of voluntary movements and motor sequences. This syndrome is assumed to follow on from an interruption of the motor...

Université de Fribourg

Distinction between hand dominance and hand preference in primates: a behavioral investigation of manual dexterity in nonhuman primates (macaques) and human subjects

Chatagny, Pauline ; Badoud, Simon ; Kaeser, Mélanie ; Gindrat, Anne-Dominique ; Savidan, Julie ; Fregosi, Michela ; Moret, Véronique ; Roulin, Christine ; Schmidlin, Eric ; Rouiller, Eric M.

In: Brain and Behavior, 2013, vol. 3, no. 5, p. 575–595

The present study aimed to determine and confront hand preference (hand chosen in priority to perform a manual dexterity task) and hand dominance (hand with best motor performance) in eight macaques (Macaca fascicularis) and in 20 human subjects (10 left-handers and 10 right-handers).Methods: Four manual dexterity tests have been executed by the monkeys, over several weeks during learning and...

Université de Fribourg

Invasion of lesion territory by regenerating fibers after spinal cord injury in adult macaque monkeys

Beaud, Marie-Laure ; Rouiller, Eric M. ; Bloch, Jocelyne ; Mir, Anis ; Schwab, M.E. ; Wannier, Thierry ; Schmidlin, Eric

In: Neuroscience, 2012, vol. 27, p. 271–282

In adult macaque monkeys subjected to an incomplete spinal cord injury (SCI), corticospinal (CS) fibers are rarely observed to grow in the lesion territory. This situation is little affected by the application of an anti-Nogo-A antibody which otherwise fosters the growth of CS fibers rostrally and caudally to the lesion. However, when using the Sternberger monoclonal-incorporated antibody 32...

Université de Fribourg

Follow-up of cortical activity and structure after lesion with laser speckle imaging and magnetic resonance imaging in nonhuman primates

Peuser, Jörn ; Belhaj-Saif, Abderraouf ; Hamadjida, Adjia ; Schmidlin, Eric ; Gindrat, Anne-Dominique ; Völker, Andreas Charles ; Zakharov, Pavel ; Hoogewoud, Henri-Marcel ; Rouiller, Eric M. ; Scheffold, Frank

In: Journal of Biomedical Optics, 2011, vol. 16, no. 09, p. 096011

The nonhuman primate model is suitable to study mechanisms of functional recovery following lesion of the cerebral cortex (motor cortex), on which therapeutic strategies can be tested. To interpret behavioral data (time course and extent of functional recovery), it is crucial to monitor the properties of the experimental cortical lesion, induced by infusion of the excitotoxin ibotenic acid. In...

Université de Fribourg

A case of polymicrogyria in macaque monkey: impact on anatomy and function of the motor system

Schmidlin, Eric ; Jouffrais, Christophe ; Freund, Patrick ; Wannier-Morino, Patrizia ; Beaud, Marie-Laure ; Rouiller, Eric M. ; Wannier, Thierry

In: BMC Neuroscience, 2009, vol. 10, p. 155

Background Polymicrogyria is a malformation of the cerebral cortex often resulting in epilepsy or mental retardation. It remains unclear whether this pathology affects the structure and function of the corticospinal (CS) system. The anatomy and histology of the brain of one macaque monkey exhibiting a spontaneous polymicrogyria (PMG monkey) were examined and compared to the brain of normal...

Université de Fribourg

Anti-Nogo-A antibody treatment promotes recovery of manual dexterity after unilateral cervical lesion in adult primates – re-examination and extension of behavioral data

Freund, Patrick ; Schmidlin, Eric ; Wannier, Thierry ; Bloch, Jocelyne ; Mir, Anis ; Schwab, Martin E. ; Rouiller, Eric M.

In: European Journal of Neuroscience, 2009, vol. 29, no. 5, p. 983 - 996

In rodents and nonhuman primates subjected to spinal cord lesion, neutralizing the neurite growth inhibitor Nogo-A has been shown to promote regenerative axonal sprouting and functional recovery. The goal of the present report was to re-examine the data on the recovery of the primate manual dexterity using refined behavioral analyses and further statistical assessments, representing secondary...