Université de Fribourg

pH-responsive nano-self-assemblies of the anticancer drug 2-hydroxyoleic acid

Prajapati, Rama ; Gontsarik, Mark ; Yaghmur, Anan ; Salentinig, Stefan

In: Langmuir, 2019, vol. 35, no. 24, p. 7954–7961

pH-responsive lipid nanocarriers have the potential to selectively target the acidic extracellular pH environment of cancer tissues and may further improve the efficacy of chemotherapeutics by minimizing their toxic side-effects. Here, we present the design and characterization of pH-sensitive nano-self-assemblies of the poorly water-soluble anticancer drug 2-hydroxyoleic acid (2OHOA) with...

Université de Fribourg

Multifunctional nano‐biointerfaces: cytocompatible antimicrobial nanocarriers from stabilizer‐free cubosomes

Zabara, Mahsa ; Senturk, Berna ; Gontsarik, Mark ; Ren, Qun ; Rottmar, Markus ; Maniura-Weber, Katharina ; Mezzenga, Raffaele ; Bolisetty, Sreenath ; Salentinig, Stefan

In: Advanced Functional Materials, 2019, p. 1904007

The rational design of alternative antimicrobial materials with reduced toxicity toward mammalian cells is highly desired due to the growing occurrence of bacteria resistant to conventional antibiotics. A promising approach is the design of lipid‐based antimicrobial nanocarriers. However, most of the commonly used polymer‐stabilized nanocarriers are cytotoxic. Herein, the design of a...

Université de Fribourg

Supramolecular structures in lipid digestion and implications for functional food delivery

Salentinig, Stefan

In: Current Opinion in Colloid & Interface Science, 2019, vol. 39, p. 190–201

The daily diet is important for our survival, health, and wellbeing. Functional food materials, which tailor the digestion process, can help maintaining and even improving human health and lifestyle. Knowledge on how food products, particularly food emulsions such as milk, interact with the digestive system, where they transform into supramolecular structures, can have a direct impact on the...

Université de Fribourg

Excitonic channels from bio-inspired templated supramolecular assembly of J-aggregate nanowires

Anantharaman, Surendra B. ; Messmer, Daniel ; Sadeghpour, Amin ; Salentinig, Stefan ; Nüescha, Frank ; Heier, Jakob

In: Nanoscale, 2019, vol. 11, no. 14, p. 6929–6938

Supramolecular assemblies with controlled morphology are of paramount importance for energy transport in organic semiconductors. Despite considerable freedom in molecular design, the preparation of dyes that form one dimensional J-aggregates is challenging. Here, we demonstrate a simple and effective route to functionalize dendronized polymers (DPs) with J-aggregates to construct tubular...