Université de Fribourg

Diversity of cortico-descending projections: histological and diffusion MRI characterization in the monkey

Innocenti, Giorgio M ; Caminiti, Roberto ; Rouiller, Eric M ; Knott, Graham ; Dyrby, Tim B ; Descoteaux, Maxime ; Thiran, Jean-Philippe

In: Cerebral Cortex, 2018, p. -

The axonal composition of cortical projections originating in premotor, supplementary motor (SMA), primary motor (a4), somatosensory and parietal areas and descending towards the brain stem and spinal cord was characterized in the monkey with histological tract tracing, electron microscopy (EM) and diffusion MRI (dMRI). These 3 approaches provided complementary information. Histology provided...

Université de Fribourg

Nogo-A–specific antibody treatment enhances sprouting and functional recovery after cervical lesion in adult primates

Freund, Patrick ; Schmidlin, Eric ; Wannier, Thierry ; Bloch, Jocelyne ; Mir, Anis ; Schwab, Martin E ; Rouiller, Eric M

In: Nature Medicine, 2006/12/

In rodents, after spinal lesion, neutralizing the neurite growth inhibitor Nogo-A promotes axonal sprouting and functional recovery. To evaluate this treatment in primates, 12 monkeys were subjected to cervical lesion. Recovery of manual dexterity and sprouting of corticospinal axons were enhanced in monkeys treated with Nogo-A–specific antibody as compared to monkeys treated with control...