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Université de Fribourg

Breast cancer stem cells with tumor- versus metastasis-initiating capacities are modulated by TGFBR1 inhibition

Fico, Flavia ; Bousquenaud, Mélanie ; Rüegg, Curzio ; Santamaria-Martínez, Albert

In: Stem Cell Reports, 2019, vol. 13, no. 1, p. 1–9

Cancer stem cells (CSCs) are defined by their ability to regenerate a tumor upon transplantation. However, it is not yet clear whether tumors contain a single CSC population or different subsets of cells with mixed capacities for initiating primary and secondary tumors. Using two different identification strategies, we studied the overlap between metastatic stem cells and tumor-initiating...

Université de Fribourg

MAGI1 mediates eNOS activation and NO production in endothelial cells in response to fluid shear stress

Ghimire, Kedar ; Zaric, Jelena ; Alday-Parejo, Begoña ; Seebach, Jochen ; Bousquenaud, Mélanie ; Stalin, Jimmy ; Bieler, OrcID, Grégory ; Schnittler, Hans-Joachim ; Rüegg, Curzio

In: Cells, 2019, vol. 8, no. 5, p. 388

Fluid shear stress stimulates endothelial nitric oxide synthase (eNOS) activation and nitric oxide (NO) production through multiple kinases, including protein kinase A (PKA), AMP-activated protein kinase (AMPK), AKT and Ca2+/calmodulin-dependent protein kinase II (CaMKII). Membrane-associated guanylate kinase (MAGUK) with inverted domain structure-1 (MAGI1) is an adaptor protein that...

Université de Fribourg

Type I interferon/IRF7 axis instigates chemotherapy-induced immunological dormancy in breast cancer

Lan, Qiang ; Peyvandi, Sanam ; Duffey, Nathalie ; Huang, Yu-Ting ; Barras, David ; Held, Werner ; Richard, François ; Delorenzi, Mauro ; Sotiriou, Christos ; Desmedt, Christine ; Lorusso, Girieca ; Rüegg, Curzio

In: Oncogene, 2019, vol. 38, no. 15, p. 2814–2829

Neoadjuvant and adjuvant chemotherapies provide survival benefits to breast cancer patients, in particular in estrogen receptor negative (ER−) cancers, by reducing rates of recurrences. It is assumed that the benefits of (neo)adjuvant chemotherapy are due to the killing of disseminated, residual cancer cells, however, there is no formal evidence for it. Here, we provide experimental...

Université de Fribourg

Not just fundamental research: education, equal opportunities, knowledge and technology transfer, and communication at the nccr bio-inspired materials

Capper, Scott ; Haskal, Eliav ; Kilbinger, Andreas ; Montero de Espinosa, Lucas ; Rothen-Rutishauser, Barbara ; Rüegg, Curzio ; Weder, Christoph

In: CHIMIA International Journal for Chemistry, 2019, vol. 73, no. 1, p. 86–89

Besides conducting excellent fundamental research in domains of strategic importance, the National Centers of Competence in Research (NCCRs) also aim to become centers of reference for education, equal opportunities, and knowledge and technology transfer. These activities are supported by a communication strategy focused on specific target groups. This article describes some of the main...

Université de Fribourg

A bio-inspired amplification cascade for the detection of rare cancer cells

Rüegg, Curzio ; Reis, Corine ; Rafiee, Sarah ; Rodriguez-Lorenzoa, Laura ; List, Jonathan ; Rothen-Rutishauser, Barbara ; Mayer, Michael ; Petri-Fink, Alke

In: CHIMIA International Journal for Chemistry, 2019, vol. 73, no. 1, p. 63–68

The main cause of cancer-related death is due to cancer cell spreading and formation of secondary tumors in distant organs, the so-called metastases. Metastatic cancer cells are detectable in the blood of cancer patients as circulating tumor cells (CTC) and may be exploited for prognostic and monitoring purposes, including in breast cancer. Due to their very low frequency, however, their...

Université de Fribourg

Characterization and in vivo validation of a three-dimensional multi-cellular culture model to study heterotypic interactions in colorectal cancer cell growth, invasion and metastasis

Cattin, Sarah ; Ramont, Laurent ; Rüegg, Curzio

In: Frontiers in Bioengineering and Biotechnology, 2018, vol. 6, p. -

Colorectal cancer (CRC) is the third cause of cancer-related mortality in industrialized countries. Local invasion and metastasis formation are events associated with poor prognosis for which today there are no effective therapeutic options. Invasion and metastasis are strongly modulated by cells of the tumor microenvironment (TME), in particular fibroblasts and endothelial cells. Unraveling...

Université de Fribourg

Obesity promotes the expansion of metastasis-initiating cells in breast cancer

Bousquenaud, Mélanie ; Fico, Flavia ; Solinas, Giovanni ; Rüegg, Curzio ; Santamaria-Martínez, Albert

In: Breast Cancer Research, 2018, vol. 20, no. 1, p. 104

Obesity is a strong predictor of poor prognosis in breast cancer, especially in postmenopausal women. In particular, tumors in obese patients tend to seed more distant metastases, although the biology behind this observation remains poorly understood.Methods: To elucidate the effects of the obese microenvironment on metastatic spread, we ovariectomized C57BL/6 J female mice and fed them...

Université de Fribourg

Baicalein inhibits acinar-to-ductal metaplasia of pancreatic acinal cell AR42J via improving the inflammatory microenvironment

Pu, Wei-Ling ; Luo, Ying-Ying ; Bai, Ru-Yu ; Guo, Ao-Wei ; Zhou, Kun ; Zhang, Yun-Sha ; Miao, Lin ; Rüegg, Curzio ; Hottiger, Micheal O. ; Gao, Xiu-Mei ; Sun, Li-Kang

In: Journal of Cellular Physiology, 2018, vol. 233, no. 8, p. 5747–5755

Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive cancers. Recent research has demonstrated that chronic pancreatitis (CP) is associated with an increased risk of PDAC, partly due to acinar-to-ductal metaplasia (ADM). Baicalein has been shown to exert anti-inflammatory and anti-tumor effects for CP or PDAC, respectively. The aim of our study was to investigate the effect...

Université de Fribourg

Targeting tumor-associated macrophages by anti-tumor Chinese materia medica

Pu, Wei-ling ; Sun, Li-kang ; Gao, Xiu-mei ; Rüegg, Curzio ; Cuendet, Muriel ; Hottiger, Micheal O. ; Zhou, Kun ; Miao, Lin ; Zhang, Yun-sha ; Gebauer, Margaret

In: Chinese Journal of Integrative Medicine, 2017, vol. 23, no. 10, p. 723–732

Tumor-associated macrophages (TAMs) play a key role in all stages of tumorigenesis and tumor progression. TAMs secrete different kinds of cytokines, chemokines, and enzymes to affect the progression, metastasis, and resistance to therapy depending on their state of reprogramming. Therapeutic benefit in targeting TAMs suggests that macrophages are attractive targets for cancer treatment....