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Université de Fribourg

Platelet interactions with liver sinusoidal endothelial cells and hepatic stellate cells lead to hepatocyte proliferation

Meyer, Jeremy ; Balaphas, Alexandre ; Fontana, Pierre ; Morel, Philippe ; Robson, Simon C. ; Sadoul, Karin ; Gonelle-Gispert, Carmen ; Bühler, Léo

In: Cells, 2020, vol. 9, no. 5, p. 1243

Background: Platelets were postulated to constitute the trigger of liver regeneration. The aim of this study was to dissect the cellular interactions between the various liver cells involved in liver regeneration and to clarify the role of platelets. (2) Methods: Primary mouse liver sinusoidal endothelial cells (LSECs) were co-incubated with increasing numbers of resting platelets, activated...