Université de Fribourg

Development and clinical validation of a blood test based on 29-gene expression for early detection of colorectal cancer

Ciarloni, Laura ; Ehrensberger, Sahar Hosseinian ; Imaizumi, Natsuko ; Monnier-Benoit, Sylvain ; Nichita, Cristina ; Myung, Seung-Jae ; Kim, Joo Sung ; Song, Si Young ; Kim, Tae Il ; Weg, Boudewijn van der ; Meier, Rémy ; Borovicka, Jan ; Beglinger, Christoph ; Vallet, Cédric ; Maerten, Philippe ; Rüegg, Curzio ; Dorta, Gian

In: Clinical Cancer Research, 2016, p. -

A blood test for colorectal cancer (CRC) screening is a valuable tool to for testing asymptomatic individuals and reducing CRC-related mortality. The objective of this study was to develop and validate a novel blood test able to differentiate patients with CRC and adenomatous polyps (AP) from individuals with a negative colonoscopy. Experimental Design: A case-control, multicenter clinical...

Université de Fribourg

Discovery of a 29-gene panel in peripheral blood mononuclear cells for the detection of colorectal cancer and adenomas using high throughput real-time PCR

Ciarloni, Laura ; Hosseinian, Sahar ; Monnier-Benoit, Sylvain ; Imaizumi, Natsuko ; Dorta, Gian ; Ruegg, Curzio

In: PLoS ONE, 2015, vol. 10, no. 4, p. e0123904

Colorectal cancer (CRC) is the second leading cause of cancer-related death in developed countries. Early detection of CRC leads to decreased CRC mortality. A blood-based CRC screening test is highly desirable due to limited invasiveness and high acceptance rate among patients compared to currently used fecal occult blood testing and colonoscopy. Here we describe the discovery and validation of a...