Université de Fribourg

Jagged1 is altered in alzheimer’s disease and regulates spatial memory processing

Marathe, Swananda ; Jaquet, Muriel ; Annoni, Jean-Marie ; Alberi, Lavinia

In: Frontiers in Cellular Neuroscience, 2017, vol. 11, p. -

Notch signaling plays an instrumental role in hippocampus-dependent memory formation and recent evidence indicates a displacement of Notch1 and a reduction its activity in hippocampal and cortical neurons from Alzheimer's disease (AD) patients. As Notch activation depends on ligand availability, we investigated whether Jagged1 expression was altered in brain specimen of AD patients. We found...

Université de Fribourg

Notch1 regulates hippocampal plasticity through interaction with the reelin pathway, glutamatergic transmission and CREB signaling

Brai, Emanuele ; Marathe, Swananda ; Astori, Simone ; Fredj, Naila Ben ; Perry, Elisabeth ; Lamy, Christophe ; Scotti, Alessandra ; Alberi, Lavinia

In: Frontiers in Cellular Neuroscience, 2015, p. 447

Notch signaling plays a crucial role in adult brain function such as synaptic plasticity, memory and olfaction. Several reports suggest an involvement of this pathway in neurodegenerative dementia. Yet, to date, the mechanism underlying Notch activity in mature neurons remains unresolved. In this work, we investigate how Notch regulates synaptic potentiation and contributes to the establishment...

Université de Fribourg

Notch in memories: points to remember

Marathe, Swananda ; Alberi, Lavinia

In: Hippocampus, 2015, vol. 25, no. 7, p. 771–778

Memory is a temporally evolving molecular and structural process, which involves changes from local synapses to complex neural networks. There is increasing evidence for an involvement of developmental pathways in regulating synaptic communication in the adult nervous system. Notch signaling has been implicated in memory formation in a variety of species. Nevertheless, the mechanism of Notch...

Université de Fribourg

Notch signaling in response to excitotoxicity induces neurodegeneration via erroneous cell cycle reentry

Marathe, Swananda ; Liu, S. ; Brai, Emanuele ; Kaczarowski, M. ; Albéri, Lavinia

In: Cell Death & Differentiation, 2015, p. -

Neurological disorders such as Alzheimer’s disease, stroke and epilepsy are currently marred by the lack of effective treatments to prevent neuronal death. Erroneous cell cycle reentry (CCR) is hypothesized to have a causative role in neurodegeneration. We show that forcing S-phase reentry in cultured hippocampal neurons is sufficient to induce neurodegeneration. We found that kainic-acid...

Université de Fribourg

Notch1 activity in the olfactory bulb is odour-dependent and contributes to olfactory behaviour

Brai, Emanuele ; Marathe, Swananda ; Zentilin, Lorena ; Giacca, Mauro ; Nimpf, Johannes ; Kretz, Robert ; Scotti, Alessandra ; Alberi, Lavinia

In: European Journal of Neuroscience, 2014, vol. 40, no. 10, p. 3436–3449

Notch signalling plays an important role in synaptic plasticity, learning and memory functions in both Drosophila and rodents. In this paper, we report that this feature is not restricted to hippocampal networks but also involves the olfactory bulb (OB). Odour discrimination and olfactory learning in rodents are essential for survival. Notch1 expression is enriched in mitral cells of the mouse...

Université de Fribourg

Notch signaling in the brain: In good and bad times

Alberi, Lavinia ; Hoey, Sarah ; Brai, Emanuele ; Scotti, Alessandra ; Marathe, Swananda

In: Ageing Research Reviews, 2013, p. -

Notch signaling is an evolutionarily conserved pathway, which is fundamental for neuronal development and specification. In the last decade, increasing evidence has pointed out an important role of this pathway beyond embryonic development, indicating that Notch also displays a critical function in the mature brain of vertebrates and invertebrates. This pathway appears to be involved in neural...