Université de Fribourg

Stereological analysis of the rhesus monkey entorhinal cortex

Piguet, Olivia ; Chareyron, Loïc J. ; Lavenex, Pamela Banta ; Amaral, David G. ; Lavenex, Pierre

In: Journal of Comparative Neurology, 2018, vol. 526, no. 13, p. 2115–2132

The entorhinal cortex is a prominent structure of the medial temporal lobe, which plays a pivotal role in the interaction between the neocortex and the hippocampal formation in support of declarative and spatial memory functions. We implemented design‐based stereological techniques to provide estimates of neuron numbers, neuronal soma size, and volume of different layers and subdivisions of...

Université de Fribourg

Functional organization of the medial temporal lobe memory system following neonatal hippocampal lesion in rhesus monkeys

Chareyron, Lo?c J. ; Lavenex, Pamela Banta ; Amaral, David G. ; Lavenex, Pierre

In: Brain Structure and Function, 2017, vol. 222, no. 9, p. 3899–3914

Hippocampal damage in adult humans impairs episodic and semantic memory, whereas hippocampal damage early in life impairs episodic memory but leaves semantic learning relatively preserved. We have previously shown a similar behavioral dissociation in nonhuman primates. Hippocampal lesion in adult monkeys prevents allocentric spatial relational learning, whereas spatial learning persists...

Université de Fribourg

The ‘when’ and the ‘where’ of single‐trial allocentric spatial memory performance in young children: Insights into the development of episodic memory

Ribordy Lambert, Farfalla ; Lavenex, Pierre ; Lavenex, Pamela Banta

In: Developmental Psychobiology, 2017, vol. 59, no. 2, p. 185–196

Allocentric spatial memory, “where” with respect to the surrounding environment, is one of the three fundamental components of episodic memory: what, where, when. Whereas basic allocentric spatial memory abilities are reliably observed in children after 2 years of age, coinciding with the offset of infantile amnesia, the resolution of allocentric spatial memory acquired over repeated...

Université de Fribourg

Improvement of allocentric spatial memory resolution in children from 2 to 4 years of age

Ribordy Lambert, Farfalla ; Lavenex, Pierre ; Lavenex, Pamela Banta

In: International Journal of Behavioral Development, 2015, vol. 39, no. 4, p. 318–331

Allocentric spatial memory, the memory for locations coded in relation to objects comprising our environment, is a fundamental component of episodic memory and is dependent on the integrity of the hippocampal formation in adulthood. Previous research from different laboratories reported that basic allocentric spatial memory abilities are reliably observed in children after 2 years of age. Based...

Université de Fribourg

No association between ApoE polymorphism and febrile seizures

Lavenex, Pierre ; Lavenex, Pamela Banta ; Cachat, François ; Gehri, Mario ; Juvet, Typhaine

In: Neurological Sciences, 2015, p. 1–6

Seizures associated with fever are a common pediatric problem, affecting about 2–7 % of children between 3 months and 5 years of age. Differentiation of febrile seizures from acute symptomatic seizures secondary to central nervous system infections or seizures associated with fever in children with epilepsy is essential to provide appropriate treatment and follow-up care. Here, we tested the...

Université de Fribourg

Human short-term spatial memory: Precision predicts capacity

Lavenex, Pamela Banta ; Boujon, , Valérie ; Ndarugendamwo, Angélique ; Lavenex, Pierre

In: Cognitive Psychology, 2015, vol. 77, p. 1–19

Here, we aimed to determine the capacity of human short-term memory for allocentric spatial information in a real-world setting. Young adults were tested on their ability to learn, on a trial-unique basis, and remember over a 1-min interval the location(s) of 1, 3, 5, or 7 illuminating pads, among 23 pads distributed in a 4 m × 4 m arena surrounded by curtains on three sides. Participants had to...

Université de Fribourg

Developmental regulation of gene expression and astrocytic processes may explain selective hippocampal vulnerability

Lavenex, Pierre ; Sugden, Steven G. ; Davis, Ryan R. ; Gregg, Jeffrey P. ; Lavenex, Pamela Banta

In: Hippocampus, 2010, p. -

The hippocampus plays a central role in the brain network that is essential for memory function. Paradoxically, the hippocampus is also the brain structure that is most sensitive to hypoxic-ischemic episodes. Here, we show that the expression of genes associated with glycolysis and glutamate metabolism in astrocytes and the coverage of excitatory synapses by astrocytic processes undergo...

Université de Fribourg

Postmortem changes in the neuroanatomical characteristics of the primate brain: Hippocampal formation

Lavenex, Pierre ; Lavenex, Pamela Banta ; Bennett, Jeffrey L. ; Amaral, David G.

In: The Journal of Comparative Neurology, 2009, vol. 512, no. 1, p. 27 - 51

Comparative studies of the structural organization of the brain are fundamental to our understanding of human brain function. However, whereas brains of experimental animals are fixed by perfusion of a fixative through the vasculature, human or ape brains are fixed by immersion after varying postmortem intervals. Although differential treatments might affect the fundamental characteristics of the...

Université de Fribourg

Spatial memory and the monkey hippocampus: not all space is created equal

Lavenex, Pamela Banta ; Lavenex, Pierre

In: Hippocampus, 2009, vol. 19, no. 1, p. 8-19

Studies of the role of the monkey hippocampus in spatial learning and memory, however few, have reliably produced inconsistent results. Whereas the role of the hippocampus in spatial learning and memory has been clearly established in rodents, studies in nonhuman primates have made a variety of claims that range from the involvement of the hippocampus in spatial memory only at relatively longer...

Université de Fribourg

Spatial relational learning persists following neonatal hippocampal lesions in macaque monkeys

Lavenex, Pierre ; Lavenex, Pamela Banta ; Amaral, David G.

In: Nature Neuroscience, 2006, vol. 10, no. 2, p. 234 - 239

The hippocampus is important for the acquisition of spatial representations of the environment and consequently in contextual memory. This suggests that the neural substrates underlying spatial cognition might be essential for remembering specific life episodes. Indeed, hippocampal lesions prevent spatial relational learning in adult rodents and monkeys, and result in profound amnesia in adult...