Université de Fribourg

Radiation-induced modifications of the tumor microenvironment promote metastasis

Rüegg, Curzio ; Monnier, Yan ; Kuonen, François ; Imaizumi, Natsuko

In: Bulletin du Cancer, 2011, vol. 98, no. 6, p. 47-57

Radiotherapy is successfully used to treat cancer. Emerging evidence, however, indicates that recurrences after radiotherapy are associated with increased local invasion, metastatic spreading and poor prognosis. Radiation-induced modifications of the tumor microenvironment have been proposed to contribute to increased aggressive tumor behavior, an effect also referred to as tumor bed effect, but...

Université de Fribourg

Emerging paradigms and questions on pro-angiogenic bone marrow-derived myelomonocytic cells

Laurent, Julien ; Touvrey, Cédric ; Botta, Francesca ; Kuonen, François ; Ruegg, Curzio

In: The International Journal of Developmental Biology, 2011, vol. 55, p. 527-534

Cancer-related inflammation has emerged in recent years as a major event contributing to tumor angiogenesis, tumor progression and metastasis formation. Bone marrow-derived and inflammatory cells promote tumor angiogenesis by providing endothelial progenitor cells that differentiate into mature endothelial cells, and by secreting pro-angiogenic factors and remodeling the extracellular matrix to...