Université de Fribourg

Asymmetric and distant effects of a unilateral lesion of the primary motor cortex on the bilateral supplementary motor areas in adult macaque monkeys

Contestabile, Alessandro. ; Colangiulo, R. ; Lucchini, Matteo ; Gindrat, Anne-Dominique ; Hamadjida, Adjia ; Kaeser, Mélanie ; Savidan, Julie ; Wyss, A. F. ; Rouiller, Eric M. ; Schmidlin, Eric

In: Journal of Neuroscience, 2018, vol. 38, no. 50, p. 10644–10656

A restricted lesion of the hand area in the primary motor cortex (M1) leads to a deficit of contralesional manual dexterity, followed by an incomplete functional recovery, accompanied by plastic changes in M1 itself and in other cortical areas on both hemispheres. Using the marker SMI-32 specific to pyramidal neurons in cortical layers III and V, we investigated the impact of a focal...

Université de Fribourg

Birth and death of a phantom

Dieguez, Sebastian ; Kaeser, Mélanie ; Roux, Camille ; Cottet, Jérôme ; Annoni, Jean-Marie ; Schmidlin, Eric

In: Annals of Clinical and Translational Neurology, 2018, vol. 5, no. 1, p. 98–101

Patients with supernumerary phantom limb report experiencing an additional limb duplicating its physical counterpart, usually following a stroke with sensorimotor disturbances. Here, we report a short-lasting case of a right upper supernumerary phantom limb with unusual visuomotor features in a healthy participant during a pure Jacksonian motor seizure unexpectedly induced by continuous...

Université de Fribourg

Role of primary motor cortex in the control of manual dexterity assessed via sequential bilateral lesion in the adult macaque monkey: A case study

Savidan, Julie ; Kaeser, Mélanie ; Belhaj-Saïf, Abderraouf ; Schmidlin, Eric ; Rouiller, Eric

In: Neuroscience, 2017, vol. 357, p. 303–324

From a case study, we describe the impact of unilateral lesion of the hand area in the primary motor cortex (M1) on manual dexterity and the role of the intact contralesional M1 in long-term functional recovery. An adult macaque monkey performed two manual dexterity tasks: (i) “modified Brinkman board” task, assessed simple precision grip versus complex precision grip, the latter involved a...

Université de Fribourg

Effects of dorsolateral prefrontal cortex lesion on motor habit and performance assessed with manual grasping and control of force in macaque monkeys

Badoud, Simon ; Borgognon, Simon ; Cottet, Jérôme ; Chatagny, Pauline ; Moret, Véronique ; Fregosi, Michela ; Kaeser, Mélanie ; Fortis, Ekaterina ; Schmidlin, Eric ; Bloch, Jocelyne ; Brunet, Jean-François ; Rouiller, Eric M.

In: Brain Structure and Function, 2017, vol. 222, no. 3, p. 1193–1206

In the context of an autologous adult neural cell ecosystem (ANCE) transplantation study, four intact adult female macaque monkeys underwent a unilateral biopsy of the dorsolateral prefrontal cortex (dlPFC) to provide the cellular material needed to obtain the ANCE. Monkeys were previously trained to perform quantitative motor (manual dexterity) tasks, namely, the “modified-Brinkman...

Université de Fribourg

Distinction between hand dominance and hand preference in primates: a behavioral investigation of manual dexterity in nonhuman primates (macaques) and human subjects

Chatagny, Pauline ; Badoud, Simon ; Kaeser, Mélanie ; Gindrat, Anne-Dominique ; Savidan, Julie ; Fregosi, Michela ; Moret, Véronique ; Roulin, Christine ; Schmidlin, Eric ; Rouiller, Eric M.

In: Brain and Behavior, 2013, vol. 3, no. 5, p. 575–595

The present study aimed to determine and confront hand preference (hand chosen in priority to perform a manual dexterity task) and hand dominance (hand with best motor performance) in eight macaques (Macaca fascicularis) and in 20 human subjects (10 left-handers and 10 right-handers).Methods: Four manual dexterity tests have been executed by the monkeys, over several weeks during learning and...

Université de Fribourg

Representation of motor habit in a sequence of repetitive reach and grasp movements performed by macaque monkeys: Evidence for a contribution of the dorsolateral prefrontal cortex

Kaeser, Mélanie ; Wannier, Thierry ; Brunet, Jean-François ; Wyss, Alexander F. ; Bloch, Jocelyne ; Rouiller, Eric M.

In: Cortex, 2012, p. -

In the context of an autologous cell transplantation study, a unilateral biopsy of cortical tissue was surgically performed from the right dorsolateral prefrontal cortex (dlPFC) in two intact adult macaque monkeys (dlPFC lesioned group), together with the implantation of a chronic chamber providing access to the left motor cortex. Three other monkeys were subjected to the same chronic chamber...

Université de Fribourg

Short-term effects of unilateral lesion of the primary motor cortex (M1) on ipsilesional hand dexterity in adult macaque monkeys

Bashir, Shahid ; Kaeser, Mélanie ; Wyss, Alexander ; Hamadjida, Adjia ; Liu, Yu ; Bloch, Jocelyne ; Brunet, Jean-François ; Belhaj-Saif, Abderraouf ; Rouiller, Eric M.

In: Brain Structure and Function, 2011, vol. 217, no. 1, p. 63-79

Although the arrangement of the corticospinal projection in primates is consistent with a more prominent role of the ipsilateral motor cortex on proximal muscles, rather than on distal muscles involved in manual dexterity, the role played by the primary motor cortex on the control of manual dexterity for the ipsilateral hand remains a matter a debate, either in the normal function or after a...

Université de Fribourg

Doublecortin-positive cells in the adult primate cerebral cortex and possible role in brain plasticity and development

Bloch, Jocelyne ; Kaeser, Mélanie ; Sadeghi, Yalda ; Rouiller, Eric M. ; Redmond, D. Eugene JR ; Brunet, Jean-François

In: The Journal of Comparative Neurology, 2011, vol. 519, no. 4, p. 775–789

We have demonstrated that cortical cell autografts might be a useful therapy in two monkey models of neurological disease: motor cortex lesion and Parkinson's disease. However, the origin of the useful transplanted cells obtained from cortical biopsies is not clear. In this report we describe the expression of doublecortin (DCX) in these cells based on reverse-transcription polymerase chain...

Université de Fribourg

Effects of unilateral motor cortex lesion on ipsilesional hand's reach and grasp performance in monkeys: relationship with recovery in the contralesional hand

Kaeser, Mélanie ; Wyss, Alexander F. ; Bashir, Shahid ; Hamadjida, Adjia ; Liu, Yu ; Bloch, Jocelyne ; Brunet, Jean-François ; Belhaj-Saif, Abderraouf ; Rouiller, Eric M.

In: Journal of Neurophysiology, 2010, p. -

Manual dexterity, a prerogative of primates, is under the control of the corticospinal (CS) tract. As 90-95% of CS axons decussate, it is assumed that this control is exerted essentially on the contralateral hand. Consistently, unilateral lesion of the hand representation in the motor cortex is followed by a complete loss of dexterity of the contralesional hand. During the months following...