Université de Fribourg

Hormonal regulation of the humoral innate immune response in Drosophila melanogaster

Flatt, Thomas ; Heyland, Andreas ; Rus, Florentina ; Porpiglia, Ermelinda ; Sherlock, Chris ; Yamamoto, Rochele ; Garbuzov, Alina ; Palli, Subba R. ; Tatar, Marc ; Silverman, Neal

In: The Journal of Experimental Biology, 2008, vol. 21, no. 1, p. 2712-2724

Juvenile hormone (JH) and 20-hydroxy-ecdysone (20E) are highly versatile hormones, coordinating development, growth, reproduction and aging in insects. Pulses of 20E provide key signals for initiating developmental and physiological transitions, while JH promotes or inhibits these signals in a stage-specific manner. Previous evidence suggests that JH and 20E might modulate innate immunity, but...

Université de Fribourg

Comparing thyroid and insect hormone signaling

Flatt, Thomas ; Moroz, Leonid L. ; Tatar, Marc ; Heyland, Andreas

In: Integrative and Comparative Biology, 2006, vol. 46, no. 6, p. 777-794

Transitions between different states of development, physiology, and life history are typically mediated by hormones. In insects, metamorphosis and reproductive maturation are regulated by an interaction between the sesquiterpenoid juvenile hormone (JH) and the steroid 20-hydroxy-ecdysone (20E). In vertebrates and some marine invertebrates, the lipophilic thyroid hormones (THs) affect...