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Università della Svizzera italiana

Chronic delivery of antibody fragments using immunoisolated cell implants as a passive vaccination tool

Belaunzaran, Osiris Marroquin ; Cordero, Maria Isabel ; Setola, Veronica ; Bianchi, Siro ; Galli, Carmela ; Bouche, Nicolas ; Mlynarik, Vladimir ; Gruetter, Rolf ; Sandi, Carmen ; Bensadoun, Jean-Charles ; Molinari, Maurizio ; Aebischer, Patrick

In: Plos one, 2011, vol. 6, no. 4, p. e18268

Background: Monoclonal antibodies and antibody fragments are powerful biotherapeutics for various debilitating diseases. However, high production costs, functional limitations such as inadequate pharmacokinetics and tissue accessibility are the current principal disadvantages for broadening their use in clinic. Methodology and Principal Findings: We report a novel method for the long-term ...

Consortium of Swiss Academic Libraries

Eddy current effects on a clinical 7T-68cm bore scanner

Kickler, Nils ; van der Zwaag, Wietske ; Mekle, Ralf ; Kober, Tobias ; Marques, Jose ; Krueger, Gunnar ; Gruetter, Rolf

In: Magnetic Resonance Materials in Physics, Biology and Medicine, 2010, vol. 23, no. 1, p. 39-43

Université de Fribourg

Astrocytic and neuronal oxidative metabolism are coupled to the rate of glutamate–glutamine cycle in the tree shrew visual cortex

Sonnay, Sarah ; Poirot, Jordan ; Just, Nathalie ; Clerc, Anne-Catherine ; Gruetter, Rolf ; Rainer, Gregor ; Duarte, João M. N.

In: Glia, 2018, vol. 66, no. 3, p. 477–491

Astrocytes play an important role in glutamatergic neurotransmission, namely by clearing synaptic glutamate and converting it into glutamine that is transferred back to neurons. The rate of this glutamate–glutamine cycle (VNT) has been proposed to couple to that of glucose utilization and of neuronal tricarboxylic acid (TCA) cycle. In this study, we tested the hypothesis that glutamatergic...