Université de Fribourg

The I-BAR protein Ivy1 is an effector of the Rab7 GTPase Ypt7 involved in vacuole membrane homeostasis

Numrich, Johannes ; Péli-Gulli, Marie-Pierre ; Arlt, Henning ; Sardu, Alessandro ; Griffith, Janice ; Levine, Tim ; Engelbrecht-Vandré, Siegfried ; Reggiori, Fulvio ; De Virgilio, Claudio ; Ungermann, Christian

In: Journal of Cell Science, 2015, vol. 128, no. 13, p. 2278–2292

Membrane fusion at the vacuole depends on a conserved machinery that includes SNAREs, the Rab7 homolog Ypt7 and its effector HOPS. Here, we demonstrate that Ypt7 has an unexpected additional function by controlling membrane homeostasis and nutrient-dependent signaling on the vacuole surface. We show that Ivy1, the yeast homolog of mammalian missing-in-metastasis (MIM), is a vacuolar effector of...