Université de Fribourg

Expression of Notch proteins in pyramidal neurons in vivo (Letter for "Reply to Gaiano et al.: Expression of Notch Proteins in Pyramidal Neurons in Vivo" Zheng, et al., 287: 24596. doi:10.1074/jbc.L112.380915)

Gaiano, Nicholas ; Alberi, Lavinia ; Liu, Shuxi

In: The Journal of Biological Chemistry, 2012, p. -

In their recent study, Zheng et al. (1) concluded that Notch1 and Notch2 are not expressed in pyramidal neurons in the postnatal mouse forebrain. This conclusion was based upon an inability to detect expression changes in vivo after presumptive deletion using their CaMKII-Cre line (2, 3). Unfortunately, the authors provided no direct evidence that they efficiently deleted Notch1 or Notch2 in...

Université de Fribourg

Neonatal stroke in mice causes long-term changes in neuronal notch-2 expression that may contribute to prolonged injury

Albéri, Lavinia ; Chi, Zhikai ; Kadam, Shilpa D. ; Mulholland, Justin D. ; Dawson, Valina L. ; Gaiano, Nicholas ; Comi, Anne M.

In: Stroke, 2010, vol. 41, no. Suppl. 1, p. S64-S71

Background and Purpose: Notch receptors (1–4) are membrane proteins that, on ligand stilumation, release their cytoplasmic domains to serve as transcription factors. Notch-2 promotes proliferation both during development and cancer, but its role in response to ischemic injury is less well understood. The purpose of this study was to understand whether Notch-2 is induced after neonatal stroke...