Université de Fribourg

The orbitofrontal cortex projects to the parvafox nucleus of the ventrolateral hypothalamus and to its targets in the ventromedial periaqueductal grey matter

Babalian, Alexandre ; Eichenberger, Simone ; Bilella, Alessandro ; Girard, Franck ; Szabolcsi, Viktoria ; Roccaro, Diana ; Alvarez-Bolado, Gonzalo ; Xu, Chun ; Celio, Marco R.

In: Brain Structure and Function, 2019, vol. 224, no. 1, p. 293–314

Although connections between the orbitofrontal cortex (OFC)—the seat of high cognitive functions—the lateral hypothalamus and the periaqueductal grey (PAG) have been recognized in the past, the precise targets of the descending fibres have not been identified. In the present study, viral tracer-transport experiments revealed neurons of the lateral (LO) and the ventrolateral (VLO) OFC...

Université de Fribourg

Efferent connections of the parvalbumin-positive (PV1) nucleus in the lateral hypothalamus of rodents

Celio, Marco R. ; Babalian, Alexandre ; Ha, Quan Hue ; Eichenberger, Simone ; Clément, Laurence ; Marti, Christiane ; Saper, Clifford B.

In: Journal of Comparative Neurology, 2013, vol. 521, no. 14, p. 3133–3153

A solitary cluster of parvalbumin-positive neurons – the PV1 nucleus – has been observed in the lateral hypothalamus of rodents. In the present study, we mapped the efferent connections of the PV1 nucleus using nonspecific antero- and retrograde tracers in rats, and chemoselective, Cre-dependent viral constructs in parvalbumin-Cre mice. In both species, the PV1 nucleus was found to project...