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    Université de Fribourg

    Characterization and in vivo validation of a three-dimensional multi-cellular culture model to study heterotypic interactions in colorectal cancer cell growth, invasion and metastasis

    Cattin, Sarah ; Ramont, Laurent ; Rüegg, Curzio

    In: Frontiers in Bioengineering and Biotechnology, 2018, vol. 6, p. -

    Colorectal cancer (CRC) is the third cause of cancer-related mortality in industrialized countries. Local invasion and metastasis formation are events associated with poor prognosis for which today there are no effective therapeutic options. Invasion and metastasis are strongly modulated by cells of the tumor microenvironment (TME), in particular fibroblasts and endothelial cells. Unraveling...

    Université de Fribourg

    Bevacizumab specifically decreases elevated levels of circulating KIT+CD11b+ cells and IL-10 in metastatic breast cancer patients

    Cattin, Sarah ; Fellay, Benoît ; Pradervand, Sylvain ; Trojan, Andreas ; Ruhstaller, Thomas ; Rüegg, Curzio ; Fürstenberger, Gregor

    In: Oncotarget, 2016, vol. 7, no. 10, p. 11137–11150

    Whether bevacizumab exerts its anti-tumor properties through systemic effects beyond local inhibition of angiogenesis and how these effects can be monitored in patients, remain largely elusive. To address these questions, we investigated bone marrow-derived cells and cytokines in the peripheral blood of metastatic breast cancer patients undergoing therapy with...