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Università della Svizzera italiana

CCR2 acts as scavenger for CCL2 during monocyte chemotaxis

Volpe, Silvia ; Cameroni, Elisabetta ; Moepps, Barbara ; Thelen, Sylvia ; Apuzzo, Tiziana ; Thelen, Marcus

In: Plos one, 2012, vol. 7, no. 5, p. e37208

Background: Leukocyte migration is essential for effective host defense against invading pathogens and during immune homeostasis. A hallmark of the regulation of this process is the presentation of chemokines in gradients stimulating leukocyte chemotaxis via cognate chemokine receptors. For efficient migration, receptor responsiveness must be maintained whilst the cells crawl on cell surfaces...

Università della Svizzera italiana

CXCR7 functions as a scavenger for CXCL12 and CXCL11

Naumann, Ulrike ; Cameroni, Elisabetta ; Pruenster, Monika ; Mahabaleshwar, Harsha ; Raz, Erez ; Zerwes, Hans-Günter ; Rot, Antal ; Thelen, Marcus

In: Plos one, 2010, vol. 5, no. 2, p. e9175

Background: CXCR7 (RDC1), the recently discovered second receptor for CXCL12, is phylogenetically closely related to chemokine receptors, but fails to couple to G-proteins and to induce typical chemokine receptor mediated cellular responses. The function of CXCR7 is controversial. Some studies suggest a signaling activity in mammalian cells and zebrafish embryos, while others indicate a decoy...

Université de Fribourg

The yeast protein kinase Sch9 adjusts V-ATPase assembly/disassembly to control pH homeostasis and longevity in response to glucose availability

Wilms, Tobias ; Swinnen, Erwin ; Eskes, Elja ; Dolz-Edo, Laura ; Uwineza, Alice ; Essche, Ruben Van ; Rosseels, Joëlle ; Zabrocki, Piotr ; Cameroni, Elisabetta ; Franssens, Vanessa ; Virgilio, Claudio De ; Smits, Gertien J. ; Winderickx, Joris

In: PLOS Genetics, 2017, vol. 13, no. 6, p. e1006835

The evolutionary conserved TOR complex 1 controls growth in response to the quality and quantity of nutrients such as carbon and amino acids. The protein kinase Sch9 is the main TORC1 effector in yeast. However, only few of its direct targets are known. In this study, we performed a genome-wide screening looking for mutants which require Sch9 function for their survival and growth. In this...

Université de Fribourg

Initiation of the TORC1-regulated G0 program requires Igo1/2, which license specific mRNAs to evade degradation via the 5'-3' mRNA decay pathway

Talarek, Nicolas ; Cameroni, Elisabetta ; Jaquenoud, Malika ; Luo, Xuan ; Bontron, Séverine ; Lippman, Soyeon ; Devgan, Geeta ; Snyder, Michael ; Broach, James R. ; De Virgilio, Claudio

In: Molecular Cell, 2010, vol. 38, no. 3, p. 345-355

Eukaryotic cell proliferation is controlled by growth factors and essential nutrients, in the absence of which cells may enter into a quiescent (G0) state. In yeast, nitrogen and/or carbon limitation causes downregulation of the conserved TORC1 and PKA signaling pathways and, consequently, activation of the PAS kinase Rim15, which orchestrates G0 program initiation and ensures proper life span by...

Université de Fribourg

Deciphering protein kinase specificity through large-scale analysis of yeast phosphorylation site motifs

Mok, Janine ; Kim, Philip M. ; Lam, Hugo Y. K. ; Piccirillo, Stacy ; Zhou, Xiuqiong ; Jeschke, Grace R. ; Sheridan, Douglas L. ; Parker, Sirlester A. ; Desai, Ved ; Jwa, Miri ; Cameroni, Elisabetta ; Niu, Hengyao ; Good, Matthew ; Remenyi, Attila ; Ma, Jia-Lin Nianhan ; Sheu, Yi-Jun ; Sassi, Holly E. ; Sopko, Richelle ; Chan, Clarence S. M. ; De Virgilio, Claudio ; Hollingsworth, Nancy M. ; Lim, Wendell A. ; Stern, David F. ; Stillman, Bruce ; Andrews, Brenda J. ; Gerstein, Mark B. ; Snyder, Michael ; Turk, Benjamin E.

In: Science Signaling, 2010, vol. 3, no. 109, p. ra12

Phosphorylation is a universal mechanism for regulating cell behavior in eukaryotes. Although protein kinases target short linear sequence motifs on their substrates, the rules for kinase substrate recognition are not completely understood. We used a rapid peptide screening approach to determine consensus phosphorylation site motifs targeted by 61 of the 122 kinases in Saccharomyces cerevisiae....

Université de Fribourg

Control of cellular physiology by TM9 proteins in yeast and Dictyostelium

Froquet, Romain ; Cherix, Nathalie ; Birke, Raphael ; Benghezal, Mohammed ; Cameroni, Elisabetta ; Letourneur, François ; Mösch, Hans-Ulrich ; De Virgilio, Claudio ; Cosson, Pierre

In: Journal of Biological Chemistry, 2008, vol. 283, no. 11, p. 6764-6772

TM9 proteins constitute a well defined family, characterized by the presence of a large variable extracellular domain and nine putative transmembrane domains. This family is highly conserved throughout evolution and comprises three members in Dictyostelium discoideum and Saccharomyces cerevisiae and four in humans and mice. In Dictyostelium, previous analysis demonstrated...

Université de Fribourg

Caffeine extends yeast lifespan by targeting TORC1

Wanke, Valeria ; Cameroni, Elisabetta ; Uotila, Aino ; Piccolis, Manuele ; Urban, Jörg ; Loewith, Robbie ; De Virgilio, Claudio

In: Molecular Microbiology, 2008, vol. 69, no. 1, p. 277 - 285

Dietary nutrient limitation (dietary restriction) is known to increase lifespan in a variety of organisms. Although the molecular events that couple dietary restriction to increased lifespan are not clear, studies of the model eukaryote Saccharomyces cerevisiae have implicated several nutrient-sensitive kinases, including the target of rapamycin complex 1 (TORC1), Sch9, protein kinase A (PKA) and...

Université de Fribourg

The evolutionary conserved BER1 gene is involved in microtubule stability in yeast

Fiechter, Vincent ; Cameroni, Elisabetta ; Cerutti, Lorenzo ; De Virgilio, Claudio ; Barral, Yves ; Fankhauser, Christian

In: Current Genetics, 2008, vol. 53, no. 2, p. 107-115

In yeast, microtubules are dynamic filaments necessary for spindle and nucleus positioning, as well as for proper chromosome segregation. We identify a function for the yeast gene BER1 (Benomyl REsistant 1) in microtubule stability. BER1 belongs to an evolutionary conserved gene family whose founding member Sensitivity to Red light Reduced is involved in red-light perception and...