Université de Fribourg

Multifunctional nano‐biointerfaces: cytocompatible antimicrobial nanocarriers from stabilizer‐free cubosomes

Zabara, Mahsa ; Senturk, Berna ; Gontsarik, Mark ; Ren, Qun ; Rottmar, Markus ; Maniura-Weber, Katharina ; Mezzenga, Raffaele ; Bolisetty, Sreenath ; Salentinig, Stefan

In: Advanced Functional Materials, 2019, p. 1904007

The rational design of alternative antimicrobial materials with reduced toxicity toward mammalian cells is highly desired due to the growing occurrence of bacteria resistant to conventional antibiotics. A promising approach is the design of lipid‐based antimicrobial nanocarriers. However, most of the commonly used polymer‐stabilized nanocarriers are cytotoxic. Herein, the design of a...

Université de Fribourg

Gelation, phase behavior, and dynamics of β-Lactoglobulin amyloid fibrils at varying concentrations and ionic strengths

Bolisetty, Sreenath ; Harnau, Ludger ; Jung, Jin-mi ; Mezzenga, Raffaele

In: Biomacromolecules, 2012, vol. 13, no. 10, p. 3241–3252

We have investigated the thermodynamic and dynamic behavior of multistranded β-lactoglobulin protein fibrils in water, by combining static, dynamic, and depolarized dynamic light scattering (SLS, DLS, DDLS), small angle neutron scattering (SANS), rheology, and cryogenic transmission electron microscopy (cryo-TEM). We focus on the region of the phase diagram at which ionic strength and...

Université de Fribourg

Controlling hierarchical self-assembly in supramolecular tailed-dendron systems

Merlet-Lacroix, Nathalie ; Rao, Jingyi ; Zhang, Afang ; Schlüter, A. Dieter ; Bolisetty, Sreenath ; Ruokolainen, Janne ; Mezzenga, Raffaele

In: Macromolecules, 2010, vol. 43, no. 10, p. 4752–4760

We study the self-assembly of a dendritic macromolecular system formed by a second-generation dendron with pH-responsive end groups and with a polymer chain emanating from its focal point, typically referred to as dendron-coil system. We use supramolecular ionic interactions to attach to the periphery of the dendrons sulfate-terminated alkyl tails of various lengths. The resulting ionic complexes...