Université de Fribourg

Reduced skeletal muscle protein turnover and thyroid hormone metabolism in adaptive thermogenesis that facilitates body fat recovery during weight regain

Calonne, Julie ; Isacco, Laurie ; Miles-Chan, Jennifer ; Arsenijevic, Denis ; Montani, Jean-Pierre ; Guillet, Christelle ; Boirie, Yves ; Dulloo, Abdul G.

In: Frontiers in Endocrinology, 2019, vol. 10, p. -

Objective: The recovery of body composition after weight loss is characterized by an accelerated rate of fat recovery (preferential catch-up fat) resulting partly from an adaptive suppression of thermogenesis. Although the skeletal muscle has been implicated as an effector site for such thrifty (energy conservation) metabolism driving catch-up fat, the underlying mechanisms remain to be...