Université de Fribourg

Arp3 controls the podocyte architecture at the kidney filtration barrier

Schell, Christoph ; Sabass, Benedikt ; Helmstaedter, Martin ; Geist, Felix ; Abed, Ahmed ; Yasuda-Yamahara, Mako ; Sigle, August ; Maier, Jasmin I. ; Grahammer, Florian ; Siegerist, Florian ; Artelt, Nadine ; Endlich, Nicole ; Kerjaschki, Dontscho ; Arnold, Hans-Henning ; Dengjel, Jörn ; Rogg, Manuel ; Huber, Tobias B.

In: Developmental Cell, 2018, vol. 47, no. 6, p. 741-757.e8

Podocytes, highly specialized epithelial cells, build the outer part of the kidney filtration barrier and withstand high mechanical forces through a complex network of cellular protrusions. Here, we show that Arp2/3-dependent actin polymerization controls actomyosin contractility and focal adhesion maturation of podocyte protrusions and thereby regulates formation, maintenance, and capacity...