Université de Fribourg

The flavonoid 4,4′-dimethoxychalcone promotes autophagy-dependent longevity across species

Carmona-Gutierrez, Didac ; Zimmermann, Andreas ; Kainz, Katharina ; Pietrocola, Federico ; Chen, Guo ; Maglioni, Silvia ; Schiavi, Alfonso ; Nah, Jihoon ; Mertel, Sara ; Beuschel, Christine B. ; Castoldi, Francesca ; Sica, Valentina ; Trausinger, Gert ; Raml, Reingard ; Sommer, Cornelia ; Schroeder, Sabrina ; Hofer, Sebastian J. ; Bauer, Maria A. ; Pendl, Tobias ; Tadic, Jelena ; Dammbrueck, Christopher ; Hu, Zehan ; Ruckenstuhl, Christoph ; Eisenberg, Tobias ; Durand, Sylvere ; Bossut, Noélie ; Aprahamian, Fanny ; Abdellatif, Mahmoud ; Sedej, Simon ; Enot, David P. ; Wolinski, Heimo ; Dengjel, Jörn ; Kepp, Oliver ; Magnes, Christoph ; Sinner, Frank ; Pieber, Thomas R. ; Sadoshima, Junichi ; Ventura, Natascia ; Sigrist, Stephan J. ; Kroemer, Guido ; Madeo, Frank

In: Nature Communications, 2019, vol. 10, no. 1, p. 651

Ageing constitutes the most important risk factor for all major chronic ailments, including malignant, cardiovascular and neurodegenerative diseases. However, behavioural and pharmacological interventions with feasible potential to promote health upon ageing remain rare. Here we report the identification of the flavonoid 4,4′- dimethoxychalcone (DMC) as a natural compound with anti-ageing...

Université de Fribourg

Dietary spermidine for lowering high blood pressure

Eisenberg, Tobias ; Abdellatif, Mahmoud ; Zimmermann, Andreas ; Schroeder, Sabrina ; Pendl, Tobias ; Harger, Alexandra ; Stekovic, Slaven ; Schipke, Julia ; Magnes, Christoph ; Schmidt, Albrecht ; Ruckenstuhl, Christoph ; Dammbrueck, Christopher ; Gross, Angelina S. ; Herbst, Viktoria ; Carmona-Gutierrez, Didac ; Pietrocola, Federico ; Pieber, Thomas R. ; Sigrist, Stephan J. ; Linke, Wolfgang A. ; Mühlfeld, Christian ; Sadoshima, Junichi ; Dengjel, Joern ; Kiechl, Stefan ; Kroemer, Guido ; Sedej, Simon ; Madeo, Frank

In: Autophagy, 2017, vol. 0, no. 0, p. 1–3

Loss of cardiac macroautophagy/autophagy impairs heart function, and evidence accumulates that an increased autophagic flux may protect against cardiovascular disease. We therefore tested the protective capacity of the natural autophagy inducer spermidine in animal models of aging and hypertension, which both represent major risk factors for the development of cardiovascular disease. Dietary...