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Université de Fribourg

Striatal reactivity to reward under threat-of-shock and working memory load in adults at increased familial risk for major depression: A preliminary study

Gaillard, Claudie ; Guillod, Matthias ; Ernst, Monique ; Federspiel, Andrea ; Schoebi, Dominik ; Recabarren, Romina Evelyn ; Ouyang, Xinyi ; Mueller-Pfeiffer, Christoph ; Horschg, Antje ; Homan, Philipp ; Wiest, Roland ; Hasler, Gregor ; Martin-Soelch, Chantal

In: NeuroImage: Clinical, 2020, vol. 26, p. 102193

Introduction: Anhedonia, a core symptom of Major Depressive Disorder (MDD), manifests as a lack or loss of motivation as reflected by decreased reward responsiveness, at both behavioral and neural (i.e., striatum) levels. Exposure to stressful life events is another important risk factor for MDD. However, the mechanisms linking reward-deficit and stress to MDD remain poorly understood. Here,...

Université de Fribourg

Striatal responsiveness to reward under threat‐of‐shock and working memory load : A preliminary study

Gaillard, Claudie ; Guillod, Matthias ; Ernst, Monique ; Torrisi, Salvatore ; Federspiel, Andrea ; Schoebi, Dominik ; Recabarren, Romina E. ; Ouyang, Xinyi ; Mueller-Pfeiffer, Christoph ; Horsch, Antje ; Homan, Philipp ; Wiest, Roland ; Hasler, Gregor ; Martin-Soelch, Chantal

In: Brain and Behavior, 2019, no. 9, p. 1-21

Introduction: Reward and stress are important determinants of motivated behaviors. Striatal regions play a crucial role in both motivation and hedonic processes. So far, little is known on how cognitive effort interacts with stress to modulate reward processes. This study examines how cognitive effort (load) interacts with an unpredictable acute stressor (threat-of-shock) to modulate motivational...