Affiner les résultats

Collection spécifique


Université de Fribourg

Planning of spatially-oriented locomotion following focal brain damage in humans: A pilot study

Hicheur, Halim ; Boujon, Carole ; Wong, Cuebong ; Pham, Quang-Cuong ; Annoni, Jean-Marie ; Bihl, Titus

In: Behavioural Brain Research, 2016, vol. 301, p. 33–42

Motor impairments in human gait following stroke or focal brain damage are well documented. Here, we investigated whether stroke and/or focal brain damage also affect the navigational component of spatially oriented locomotion. Ten healthy adult participants and ten adult brain-damaged patients had to walk towards distant targets from different starting positions (with vision or blindfolded). No...

Université de Fribourg

Whole-scalp EEG mapping of somatosensory evoked potentials in macaque monkeys

Gindrat, Anne-Dominique ; Quairiaux, Charles ; Britz, Juliane ; Brunet, Denis ; Lanz, Florian ; Michel, Christoph M. ; Rouiller, Eric M.

In: Brain Structure and Function, 2015, vol. 220, no. 4, p. 2121–2142

High-density scalp EEG recordings are widely used to study whole-brain neuronal networks in humans non-invasively. Here, we validate EEG mapping of somatosensory evoked potentials (SSEPs) in macaque monkeys (Macaca fascicularis) for the long-term investigation of large-scale neuronal networks and their reorganisation after lesions requiring a craniotomy. SSEPs were acquired from 33 scalp...

Université de Fribourg

Changes in corticospinal transmission following 8 weeks of ankle joint immobilization

Leukel, Christian ; Taube, Wolfgang ; Rittweger, Jörn ; Gollhofer, Albert ; Ducos, Michel ; Weber, Tobias ; Lundbye-Jensen, Jesper

In: Clinical Neurophysiology, 2015, vol. 126, no. 1, p. 131–139

Joint immobilization has previously been shown to modulate corticospinal excitability. The present study investigated changes in the excitability of distinct fractions of the corticospinal pathway by means of conditioning the H-reflex with transcranial magnetic stimulation (TMS) of the primary motor cortex (Hcond). This method allows assessment of transmission in fast (monosynaptic) and slow(er)...

Université de Fribourg

Distinct contributions of Brodmann areas 1 and 2 to body ownership

Martuzzi, Roberto ; Zwaag, Wietske van der ; Dieguez, Sebastian ; Serino, Andrea ; Gruetter, Rolf ; Blanke, Olaf

In: Social Cognitive and Affective Neuroscience, 2015, p. nsv031

Although body ownership—i.e. the feeling that our bodies belong to us—modulates activity within the primary somatosensory cortex (S1), it is still unknown whether this modulation occurs within a somatotopically defined portion of S1. We induced an illusory feeling of ownership for another person’s finger by asking participants to hold their palm against another person’s palm and to stroke...

Université de Fribourg

A map of brain neuropils and fiber systems in the ant Cardiocondyla obscurior

Bressan, Joris M. A. ; Benz, Martin ; Oettler, Jan ; Heinze, Jürgen ; Hartenstein, Volker ; Sprecher, Simon G.

In: Frontiers in Neuroanatomy, 2015, vol. 8, p. 166

A wide spectrum of occupied ecological niches and spectacular morphological adaptations make social insects a prime object for comparative neuroanatomical studies. Eusocial insects have evolved complex societies based on caste polyphenism. A diverse behavioral repertoire of morphologically distinct castes of the same species requires a high degree of plasticity in the central nervous system. We...

Université de Fribourg

Influence of anti-Nogo-A antibody treatment on the reorganization of callosal connectivity of the premotor cortical areas following unilateral lesion of primary motor cortex (M1) in adult macaque monkeys

Hamadjida, Adjia ; Wyss, Alexander F. ; Mir, Anis ; Schwab, Martin E. ; Belhaj-Saif, Abderaouf ; Rouiller, Eric M.

In: Experimental Brain Research, 2012, vol. 223, no. 3, p. 321-340

Following unilateral lesion of the primary motor cortex, the reorganization of callosal projections from the intact hemisphere to the ipsilesional premotor cortex (PM) was investigated in 7 adult macaque monkeys, in absence of treatment (control; n = 4) or treated with function blocking antibodies against the neurite growth inhibitory protein Nogo-A (n = 3). After functional recovery, though...

Université de Fribourg

Invasion of lesion territory by regenerating fibers after spinal cord injury in adult macaque monkeys

Beaud, Marie-Laure ; Rouiller, Eric M. ; Bloch, Jocelyne ; Mir, Anis ; Schwab, M.E. ; Wannier, Thierry ; Schmidlin, Eric

In: Neuroscience, 2012, vol. 27, p. 271–282

In adult macaque monkeys subjected to an incomplete spinal cord injury (SCI), corticospinal (CS) fibers are rarely observed to grow in the lesion territory. This situation is little affected by the application of an anti-Nogo-A antibody which otherwise fosters the growth of CS fibers rostrally and caudally to the lesion. However, when using the Sternberger monoclonal-incorporated antibody 32...

Université de Fribourg

Enriched and deprived sensory experience induces structural changes and rewires connectivity during the postnatal development of the brain

Bengoetxea, Harkaitz ; Ortuzar, Naiara ; Bulnes, Susana ; Rico-Barrio, Irantzu ; Lafuente, José Vicente ; Argandoña, Enrike G.

In: Neural Plasticity, 2012, p. 305693

During postnatal development, sensory experience modulates cortical development, inducing numerous changes in all of the components of the cortex. Most of the cortical changes thus induced occur during the critical period, when the functional and structural properties of cortical neurons are particularly susceptible to alterations. Although the time course for experience-mediated sensory...

Université de Fribourg

Short-term effects of unilateral lesion of the primary motor cortex (M1) on ipsilesional hand dexterity in adult macaque monkeys

Bashir, Shahid ; Kaeser, Mélanie ; Wyss, Alexander ; Hamadjida, Adjia ; Liu, Yu ; Bloch, Jocelyne ; Brunet, Jean-François ; Belhaj-Saif, Abderraouf ; Rouiller, Eric M.

In: Brain Structure and Function, 2011, vol. 217, no. 1, p. 63-79

Although the arrangement of the corticospinal projection in primates is consistent with a more prominent role of the ipsilateral motor cortex on proximal muscles, rather than on distal muscles involved in manual dexterity, the role played by the primary motor cortex on the control of manual dexterity for the ipsilateral hand remains a matter a debate, either in the normal function or after a...

Université de Fribourg

Autologous adult cortical cell transplantation enhances functional recovery following unilateral lesion of motor cortex in primates: a pilot study

Kaeser, Melanie ; Brunet, Jean-Francois ; Wyss, Alexander ; Belhaj-Saif, Abderraouf ; Liu, Yu ; Hamadjida, Adjia ; Rouiller, Eric ; Bloch, Jocelyne

In: Neurosurgery, 2011, vol. 68, no. 5, p. 1405-1417

BACKGROUND: Although cell therapy is a promising approach after cerebral cortex lesion, few studies assess quantitatively its behavioral gain in nonhuman primates. Furthermore, implantations of fetal grafts of exogenous stem cells are limited by safety and ethical issues.OBJECTIVE: To test in nonhuman primates the transplantation of autologous adult neural progenitor cortical cells with...