In: PLoS ONE, 2010, vol. 5, no. 10, p. e13681
Biochemical purifications from mammalian cells and Xenopus oocytes revealed that vertebrate Mi-2 proteins reside in multisubunit NuRD (Nucleosome Remodeling and Deacetylase) complexes. Since all NuRD subunits are highly conserved in the genomes of C. elegans and Drosophila, it was suggested that NuRD complexes also exist in invertebrates. Recently, a novel dMec complex, composed of dMi-2 and...
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In: BMC Developmental Biology, 2010, vol. 10, no. 78, p. 78
Background: Hox genes play a central role in axial patterning during animal development. They are clustered in the genome and specify cell fate in sequential domains along the anteroposterior (A-P) body axis in a conserved order that is co-linear with their relative genomic position. In the soil worm Caenorhabditis elegans, this striking rule of co-linearity is broken by the anterior Hox gene...
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In: Science Signaling, 2010, vol. 3, no. 109, p. ra12
Phosphorylation is a universal mechanism for regulating cell behavior in eukaryotes. Although protein kinases target short linear sequence motifs on their substrates, the rules for kinase substrate recognition are not completely understood. We used a rapid peptide screening approach to determine consensus phosphorylation site motifs targeted by 61 of the 122 kinases in Saccharomyces cerevisiae....
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In: Developmental Biology, 2007, vol. 206, no. 2, p. 469-479
The fate of the vulval cells in Caenorhabditis elegans is specified, at least in part, through a highly conserved RTK/Ras mediated signaling cascade that negatively regulates the activity of the ETS-like transcription factor LIN-1. The Hox gene lin-39 functions downstream of both, the LIN-3/RTK/Ras pathway and LIN-1 and plays a pivotal role in controlling vulva cell competence and...
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Thèse de doctorat : Université de Fribourg, 2006 ; no. 1532.
Les complexes multi-protéiques remodelant la chromatine ont été démontrés comme étant impliqués dans différents procédés tels la transcription, la réplication, l’assemblage de la chromatine et la condensation des chromosomes. Des mutations dans les composants de ces complexes multi-protéiques causent diverses maladies chez l’être humain, comme la maladie d’Alzheimer ou...
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In: Developmental Biology, 2007, vol. 302, no. 2, p. 661–669
The Notch signaling pathway controls growth, differentiation and patterning in divergent animal phyla; in humans, defective Notch signaling has been implicated in cancer, stroke and neurodegenerative disorders. Despite its developmental and medical significance, little is known about the factors that render cells to become competent for Notch signaling. Here we show that during vulval development...
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In: Nature, 2003, vol. 426, p. 620
The group of enzymes known as TOR (for 'target of rapamycin') kinases regulates cell growth and proliferation in response to nutrients and hormone-dependent mitogenic signals1, 2. Here we show that TOR deficiency in the nematode Caenorhabditis elegans more than doubles its natural lifespan. This new function for TOR signalling in ageing control may represent a link between...
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In: Journal of Theoretical Biology, 2004, vol. 228(2), p. 241
Understanding the mechanisms that promote coexistence among species is a fundamental problem in evolutionary ecology. Such mechanisms include environmental noise, spatial population structure, density dependence, and genetic variation. In natural populations such factors may exert combined effects on coexistence. Thus, to disentangle the contribution of several factors to coexistence, their...
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In: Genomics, 2004, vol. 84, p. 320-330
Down syndrome (DS), as a phenotypic result of trisomy 21, is the most frequent aneuploidy at birth and the most common known genetic cause of mental retardation. DS is also characterized by other phenotypes affecting many organs, including brain, muscle, heart, limbs, gastrointestinal tract, skeleton, and blood. Any of the human chromosome 21 (Hsa21) genes may contribute to some of the DS...
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