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Université de Fribourg

Dynamic and biocompatible thermo-responsive magnetic hydrogels that respond to an alternating magnetic field

Crippa, Federica ; Moore, Thomas L. ; Mortato, Mariangela ; Geers, Christoph ; Haeni, Laetitia ; Hirt, Ann M. ; Rothen-Rutishauser, Barbara ; Petri-Fink, Alke

In: Journal of Magnetism and Magnetic Materials, 2017, vol. 427, p. 212–219

Magnetic thermo-responsive hydrogels are a new class of materials that have recently attracted interest in biomedicine due to their ability to change phase upon magnetic stimulation. They have been used for drug release, magnetic hyperthermia treatment, and can potentially be engineered as stimuli-responsive substrates for cell mechanobiology. In this regard, we propose a series of magnetic...

Université de Fribourg

Superresolution microscopy of the volume phase transition of pNIPAM microgels

Conley, Gaurasundar M. ; Nöjd, Sofi ; Braibanti, Marco ; Schurtenberger, Peter ; Scheffold, Frank

In: Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2016, vol. 499, p. 18–23

Hierarchical polymer structures such as pNIPAM microgels have been extensively studied for their ability to undergo structural and physical transformations that can be controlled by external stimuli such as temperature, pH or solvent composition. However, a direct three-dimensional visualization of individual particles in-situ has so far been hindered by insufficient resolution, with optical...

Université de Fribourg

A guide to investigating colloidal nanoparticles by cryogenic transmission electron microscopy: pitfalls and benefits

Monnier, Christophe A. ; Thévenaz, David C. ; Balog, Sandor ; Fiore, Gina L. ; Vanhecke, Dimitri ; Rothen-Rutishauser, Barbara ; Petri-Fink, Alke

In: AIMS Biophysics, 2015, vol. 2, no. 3, p. 245–258

Synthetic colloidal nanoparticles are nowadays omnipresent. Nonetheless, adequately characterizing them and interpreting the data is challenging, as their surrounding environment, e.g. the medium they are dispersed in, is often an active contributor to their size, morphology and structural integrity. In this regard, cryo-transmission electron microscopy (cryo-TEM) is an ideal methodology. This...

Université de Fribourg

Filling polymersomes with polymers by peroxidase-catalyzed atom transfer radical polymerization

Dinu, Maria Valentina ; Spulber, Mariana ; Renggli, Kasper ; Wu, Dalin ; Monnier, Christophe A. ; Petri-Fink, Alke ; Bruns, Nico

In: Macromolecular Rapid Communications, 2015, vol. 36, no. 6, p. 507–514

Polymersomes that encapsulate a hydrophilic polymer are prepared by conducting biocatalytic atom transfer radical polymerization (ATRP) in these hollow nanostructures. To this end, ATRPase horseradish peroxidase (HRP) is encapsulated into vesicles self-assembled from poly(dimethylsiloxane)-block-poly(2-methyl-2-oxazoline) (PDMS-b-PMOXA) diblock copolymers. The vesicles are turned into...

Université de Fribourg

Insertion of Nanoparticle Clusters into Vesicle Bilayers

Bonnaud, Cécile ; Monnier, Christophe A. ; Demurtas, Davide ; Jud, Corinne ; Vanhecke, Dimitri ; Montet, Xavier ; Hovius, Ruud ; Lattuada, Marco ; Rothen-Rutishauser, Barbara ; Petri-Fink, Alke

In: ACS Nano, 2014, vol. 8, no. 4, p. 3451–3460

A major contemporary concern in developing effective liposome–nanoparticle hybrids is the present inclusion size limitation of nanoparticles between vesicle bilayers, which is considered to be around 6.5 nm in diameter. In this article, we present experimental observations backed by theoretical considerations which show that greater structures can be incorporated within vesicle membranes by...

Université de Fribourg

Synthesis of nanometer-sized rod–coil block copolymers

König, Hannah M. ; Kilbinger, Andreas F. M.

In: CHIMIA International Journal for Chemistry, 2013, vol. 67, no. 11, p. 788–790

We present the solid-supported synthesis of a linear rigid rod-like tetradeca(p-benzamide) nanorod as well as a pentadeca( p -benzamide) nanorod carrying an amide N-hexyl side chain at the center of the rod (on the 8th amino acid of the molecule). These nanorods were conjugated with solubilizing poly(ethylene glycol) chains and their solution aggregation was investigated. Both rod–coil block...

Université de Fribourg

How neurons make us jump: the neural control of stretch-Shortening cycle movements

Taube, Wolfgang ; Leukel, Christian ; Gollhofer, Albert

In: Exercise and Sport Sciences Reviews, 2012, vol. 40, no. 2, p. 106–115

How can the human central nervous system (CNS) control complex jumping movements task- and context-specifically? This review highlights the complex interaction of multiple hierarchical levels of the CNS, which work together to enable stretch-shortening cycle contractions composed of activity resulting from feedforward (preprogrammed) and feedback (reflex) loops.

Université de Fribourg

ROMP copolymers for orthogonal click functionalizations

Schaefer, Mark ; Hanik, Nils ; Kilbinger, Andreas F. M.

In: Macromolecules, 2012, p. -

The ring-opening metathesis polymerization using ruthenium carbene initiators developed by Grubbs et al. is one of the most functional group tolerant living polymerization methods known. One of the most used postpolymerization functionalization methods used today is the copper-catalyzed 1,3-dipolar cycloaddition between alkynes and organic azides. Organic azides are, however, not tolerated by...