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Université de Fribourg

Reproduction of contagious caprine pleuropneumonia reveals the ability of convalescent sera to reduce hydrogen peroxide production in vitro

Liljander, Anne ; Sacchini, Flavio ; Stoffel, †, Michael H. ; Schieck, Elise ; Stokar‑Regenscheit, Nadine ; Labroussaa, Fabien ; Heller, Martin ; Salt, Jeremy ; Frey, Joachim ; Falquet, Laurent ; Goovaerts, Danny ; Jores, Joerg

In: Veterinary Research, 2019, vol. 50, no. 1, p. 10

Contagious caprine pleuropneumonia (CCPP), caused by Mycoplasma capricolum subsp. capripneumoniae is a severe disease widespread in Africa and Asia. Limited knowledge is available on the pathogenesis of this organism, mainly due to the lack of a robust in vivo challenge model and the means to do site-directed mutagenesis. This work describes the establishment of a novel caprine challenge...

Université de Fribourg

Increased temperature disrupts the biodiversity–ecosystem functioning relationship

Parain, Elodie C. ; Rohr, Rudolf P. ; Gray, Sarah M. ; Bersier, Louis-Félix

In: The American Naturalist, 2018, vol. 193, no. 2, p. 227–239

Gaining knowledge of how ecosystems provide essential services to humans is of primary importance, especially with the current threat of climate change. Yet little is known about how increased temperature will impact the biodiversity–ecosystem functioning (BEF) relationship. We tackled this subject theoretically and experimentally. We developed a BEF theory based on mechanistic population ...

Università della Svizzera italiana

Human IL-3/GM-CSF knock-in mice support human alveolar macrophage development and human immune responses in the lung

Willinger, Tim ; Rongvaux, Anthony ; Takizawa, Hitoshi ; Yancopoulos, George D. ; Valenzuela, David M. ; Murphy, Andrew J. ; Auerbach, Wojtek ; Eynon, Elizabeth E. ; Stevens, Sean ; Manz, Markus G. ; Flavell, Richard A.

In: Proceedings of the national academy of sciences of the United States of America, 2011, vol. 108, no. 6, p. 2390-2395

Mice with a functional human immune system have the potential to allow in vivo studies of human infectious diseases and to enable vaccine testing. To this end, mice need to fully support the development of human immune cells, allow infection with human pathogens, and be capable of mounting effective human immune responses. A major limitation of humanized mice is the poor development and...

Università della Svizzera italiana

Mitochondrial dysfunction induced by a SH2 domain-targeting STAT3 inhibitor leads to metabolic synthetic lethality in cancer cells

Genini, Davide ; Brambilla, Lara ; Laurini, Erik ; Merulla, Jessica ; Civenni, Gianluca ; Pandit, Shusil ; D'Antuono, Rocco ; Perez, Laurent ; Levy, David E. ; Pricl, Sabrina ; Carbone, Giuseppina M. ; Catapano, Carlo V.

In: Proceedings of the national academy of sciences of the United States of America, 2017, vol. 114, no. 25, p. E4924-E4933

In addition to its canonical role in nuclear transcription, signal transducer and activator of transcription 3 (STAT3) is emerging as an important regulator of mitochondrial function. Here, we demonstrate that a novel inhibitor that binds with high affinity to the STAT3 SH2 domain triggers a complex cascade of events initiated by interference with mitochondrial STAT3 (mSTAT3). The...

Università della Svizzera italiana

High performance selected inversion methods for sparse matrices : direct and stochastic approaches to selected inversion

Verbosio, Fabio ; Schenk, Olaf (Dir.)

Thèse de doctorat : Università della Svizzera italiana, 2019 ; 2019INFO002.

The explicit evaluation of selected entries of the inverse of a given sparse matrix is an important process in various application fields and is gaining visibility in recent years. While a standard inversion process would require the computation of the whole inverse who is, in general, a dense matrix, state-of-the-art solvers perform a selected inversion process instead. Such approach allows...

Università della Svizzera italiana

Molecular dynamics simulations with replica-averaged structural restraints generate structural ensembles according to the maximum entropy principle

Cavalli, Andrea ; Camilloni, Carlo ; Vendruscolo, Michele

In: The journal of chemical physics, 2013, vol. 138, no. 9, p. 094112

In order to characterise the dynamics of proteins, a well-established method is to incorporate experimental parameters as replica-averaged structural restraints into molecular dynamics simulations. Here, we justify this approach in the case of interproton distance information provided by nuclear Overhauser effects by showing that it generates ensembles of conformations according to the maximum...

Università della Svizzera italiana

CXCR7 prevents excessive CXCL12-mediated downregulation of CXCR4 in migrating cortical interneurons

Abe, Philipp ; Mueller, Wiebke ; Schütz, Dagmar ; MacKay, Fabienne ; Thelen, Marcus ; Zhang, Penglie ; Stumm, Ralf

In: Development, 2014, vol. 141, no. 9, p. 1857-1863

The CXCL12/CXCR4 signaling pathway is involved in the development of numerous neuronal and non-neuronal structures. Recent work established that the atypical second CXCL12 receptor, CXCR7, is essential for the proper migration of interneuron precursors in the developing cerebral cortex. Two CXCR7-mediated functions were proposed in this process: direct modulation of β-arrestin-mediated...

Université de Neuchâtel

El ritmo acentual en treinta y tres romances de juventud atribuidos a Lope de Vega

Llamas Martínez, Jacobo ; Sánchez Jiménez, Antonio (Dir.) ; Matas Caballero, Juan (Codir.) ; Navarro Colorado, Borja (Codir.) ; Udaondo Alegre, Juan (Codir.)

Thèse de doctorat : Université de Neuchâtel, 2019.

Cette thèse est basée sur une affirmation de Lope dans le prologue des Rimas de 1604 sur la «corresponsión de las cadencias » de ses romances ; la déclaration semble faire référence à une difficulté technique liée à la distribution des accents et dans laquelle les « gente ignorante » ne réparent généralement pas. Pour résoudre les deux questions, si Lope a fait allusion à une...

Université de Neuchâtel

Essays on the supply side of raw wood

Krähenbühl, Géraud ; Farsi, Mehdi (Dir.)

Thèse de doctorat : Université de Neuchâtel, 2018 ; 2739.

L’industrie forestière suisse est un environnement complexe comprenant autant des aspects du secteur public que du secteur privé. Ainsi, l’économie publique au sens strict du terme ne peut pas pleinement s’appliquer dans ce contexte car les entreprises forestières coupent et vendent du bois brut sur le marché privé; cela s'avère d’ailleurs être une partie importante de leur...

Università della Svizzera italiana

Dynamic variation in cycling of hematopoietic stem cells in steady state and inflammation

Takizawa, Hitoshi ; Regoes, Roland R. ; Boddupalli, Chandra S. ; Bonhoeffer, Sebastian ; Manz, Markus G.

In: Journal of experimental medicine, 2011, vol. 208, no. 2, p. 273-284

Hematopoietic stem cells (HSCs) maintain blood production. How often mouse HSCs divide and whether each HSC contributes simultaneously, sequentially, or repetitively to hematopoiesis remains to be determined. We track division of 5-(and-6)-carboxyfluorescein diacetate succinimidyl ester (CFSE)–labeled HSC in vivo. We found that, in steady-state mice, bone marrow cells capable of...