In: PLOS Medicine, 2020, vol. 17, no. 11, p. e1003414
The first 1,000 days of life, i.e., from conception to age 2 years, could be a critical period for cardiovascular health. Increased carotid intima-media thickness (CIMT) is a surrogate marker of atherosclerosis. We performed a systematic review with meta- analyses to assess (1) the relationship between exposures or interventions in the first 1,000 days of life and CIMT in infants, children,...
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In: Frontiers in Microbiology, 2020, vol. 11, p. 591093
Whole genome sequencing (WGS) enables high resolution typing of bacteria up to the single nucleotide polymorphism (SNP) level. WGS is used in clinical microbiology laboratories for infection control, molecular surveillance and outbreak analyses. Given the large palette of WGS reagents and bioinformatics tools, the Swiss clinical bacteriology community decided to conduct a ring trial (RT) to...
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In: PLOS Genetics, 2019, vol. 15, no. 12, p. e1008509
Understanding how the nervous system bridges sensation and behavior requires the elucidation of complex neural and molecular networks. Forward genetic approaches, such as screens conducted in C. elegans, have successfully identified genes required to process natural sensory stimuli. However, functional redundancy within the underlying neural circuits, which are often organized with multiple...
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In: PLOS Genetics, 2020, vol. 16, no. 10, p. e1009102
Ryanodine receptors (RyR) are essential regulators of cellular calcium homeostasis and signaling. Vertebrate genomes contain multiple RyR gene isoforms, expressed in different tissues and executing different functions. In contrast, invertebrate genomes contain a single RyR-encoding gene and it has long been proposed that different transcripts generated by alternative splicing may diversify...
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Thèse de doctorat : Università della Svizzera italiana, 2020 ; 2020INFO006.
Web applications are traditionally designed having in mind a server-centric architecture, whereby the whole persistent data, dynamic state and logic of the application are stored and running on a Web server. The clients running in the Web browsers traditionally render only pre-computed views fetched from the server. Nowadays this centralized approach does not fit well with the kind of...
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In: Evolution Letters, 2020, vol. 4, no. 2, p. 94–108
Evolutionary processes, including selection, can be indirectly inferred based on patterns of genomic variation among contemporary populations or species. However, this often requires unrealistic assumptions of ancestral demography and selective regimes. Sequencing ancient DNA from temporally spaced samples can inform about past selection processes, as time series data allow direct...
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In: Physica A: Statistical Mechanics and its Applications, 2019, vol. 536, p. 121004
When the product quality is limited and the information capability is variable, we propose the enterprise enhances corporate profits by changing the relationship between market demand and external resources. We assume that the information capacity can be changed through the input of external resources. In this paper, we present a research agenda that empowers external resources to transform...
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Thèse de doctorat : Università della Svizzera italiana, 2019 ; 2019INFO014.
With the rapid development of means for producing user-generated data opportunities for collecting such data over a time-line and utilizing it for various human-aid applications are more than ever. Wearable and mobile data capture devices as well as many online data channels such as search engines are all examples of means of user data collection. Such user data could be utilized to model user...
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In: Science of The Total Environment, 2019, vol. 686, p. 212–222
Common ragweed (Ambrosia artemisiifolia L.) is a widely distributed and harmful invasive plant that is an important source of highly allergenic pollen grains and a prominent crop weed. As a result, ragweed causes huge costs to both human health and agriculture in affected areas. Efficient mitigation requires accurate mapping of ragweed densities that, until now, has not been achieved...
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Thèse de doctorat : Università della Svizzera italiana, 2019 ; 2019INFO010.
Recent advances in the development of mobile devices, equipped with multiple sensors, together with the availability of millions of applications have made these devices more pervasive in our lives than ever. The availability of the diverse set of sensors, as well as high computational power, enable information retrieval (IR) systems to sense a user’s context and personalize their results ...
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