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Università della Svizzera italiana

The contribution of active and passive mechanisms of 5mC and 5hmC removal in human T lymphocytes is differentiation- and activation-dependent

Vincenzetti, Lucia ; Leoni, Cristina ; Chirichella, Michele ; Kwee, Ivo ; Monticelli, Silvia

In: European Journal of Immunology, 2019, p. 1-15

In mammals, the 5’-methylcytosine (5mC) modification in the genomic DNA contributes to the dynamic control of gene expression. 5mC erasure is required for the activation of developmental programs and occurs either by passive dilution through DNA replication, or by enzymatic oxidation of the methyl mark to 5-hydroxymethylcytosine (5hmC), which can persist as such or undergo further oxidation...

Università della Svizzera italiana

A selective ER‐phagy exerts procollagen quality control via a Calnexin‐FAM134B complex

Forrester, Alison ; Leonibus, Chiara De ; Grumati, Paolo ; Fasana, Elisa ; Piemontese, Marilina ; Staiano, Leopoldo ; Fregno, Ilaria ; Raimondi, Andrea ; Marazza, Alessandro ; Bruno, Gemma ; Iavazzo, Maria ; Intartaglia, Daniela ; Seczynska, Marta ; van Anken, Eelco ; Conte, Ivan ; De Matteis, Maria Antonietta ; Dikic, Ivan ; Molinari, Maurizio ; Settembre, Carmine

In: The EMBO Journal, 2019, vol. 38, no. 2, p. e99847

Autophagy is a cytosolic quality control process that recognizes substrates through receptor‐mediated mechanisms. Procollagens, the most abundant gene products in Metazoa, are synthesized in the endoplasmic reticulum (ER), and a fraction that fails to attain the native structure is cleared by autophagy. However, how autophagy selectively recognizes misfolded procollagens in the ER lumen is...

Université de Fribourg

Amphiphilic nanoparticle delivery enhances the anticancer efficacy of a TLR7 ligand via local immune activation

Mottas, Inès ; Bekdemir, Ahmet ; Cereghetti, Alessandra ; Spagnuolo, Lorenzo ; Yang, Yu-Sang Sabrina ; Müller, Marie ; J.Irvine, Darrell ; Stellaccic, Francesco ; Bourquin, Carole

In: Biomaterials, 2019, vol. 190–191, p. 111–120

Although immunotherapy shows great promise for the long-term control of cancer, many tumors still fail to respond to treatment. To improve the outcome, the delivery of immunostimulants to the lymph nodes draining the tumor, where the antitumor immune response is initiated, is key. Efforts to use nanoparticles as carriers for cancer immunotherapy have generally required targeting agents and...

Université de Fribourg

The role of glacier retreat for Swiss hydropower production

Schaefli, Bettina ; Manso, Pedro ; Fischerc, Mauro ; Huss, Matthias ; Farinotti, Daniel

In: Renewable Energy, 2019, vol. 132, p. 615–627

High elevation or high latitude hydropower production (HP) strongly relies on water resources that are influenced by glacier melt and are thus highly sensitive to climate warming. Despite of the wide-spread glacier retreat since the development of HP infrastructure in the 20th century, little quantitative information is available about the role of glacier mass loss for HP. In this paper, we...

Université de Fribourg

A novel approach to estimate glacier mass balance in the Tien Shan and Pamir based on transient snowline observations

Barandun, Martina ; Huss, Matthias (Dir.)

Thèse de doctorat : Université de Fribourg, 2018 ; no 2099.

Glaciers are recognised as an excellent proxy for climate change and their centennial massloss has accelerated during the past decades. The Central Asian mountain ranges Tien Shan and Pamir host over 25,000 glaciers that have been observed to respond heterogeneous to climate change. Glacier changes in the region have very important consequences on the water availability for the densely populated...

Université de Fribourg

The reproducibility of SfM algorithms to produce detailed Digital Surface Models: the example of PhotoScan applied to a high-alpine rock glacier

Hendrickx, Hanne ; Vivero, Sebastián ; Cock, Laure De ; De Wit, Bart ; De Maeyer, Philippe ; Lambiel, Christophe ; Delaloye, Reynald ; Nyssen, Jan ; Frankl, Amaury

In: Remote Sensing Letters, 2019, vol. 10, no. 1, p. 11–20

In geomorphology, PhotoScan is a software that is used to produce Digital Surface Models (DSMs). It constructs 3D environments from 2D imagery (often taken by Unmanned Aerial Vehicles (UAV)) based on Structure-from-Motion (SfM) and Multi- View Stereo (MVS) principles. However, unpublished computer-vision algorithms used, contain random elements which can affect the accuracy of the outputs. For...

Università della Svizzera italiana

P2X7 receptor restrains pathogenic Tfh cell generation in systemic lupus erythematosus

Faliti, Caterina E. ; Gualtierotti, Roberta ; Rottoli, Elsa ; Gerosa, Maria ; Perruzza, Lisa ; Romagnani, Andrea ; Pellegrini, Giovanni ; De Ponte Conti, Benedetta ; Rossi, Riccardo L. ; Idzko, Marco ; Mazza, Emilia M.C. ; Bicciato, Silvio ; Traggiai, Elisabetta ; Meroni, Pier Luigi ; Grassi, Fabio ; Istituto Nazionale Genetica Molecolare “Romeo ed Enrica Invernizzi,” Milan, Italy

In: Journal of Experimental Medicine, 2019, vol. 216, no. 2, p. 317-336

Altered control of T follicular helper (Tfh) cells can lead to generation of autoantibodies and autoimmune manifestations. Signaling pathways that selectively limit pathogenic responses without affecting the protective function of Tfh cells are unknown. Here we show that the ATP-gated ionotropic P2X7 receptor restricts the expansion of aberrant Tfh cells and the generation of self-reactive...

Université de Fribourg

Litter decomposition driven by soil fauna, plant diversity and soil management in urban gardens

Tresch, Simon ; Frey, David ; Le Bayon, Renée-Claire ; Zanettac, Andrea ; Rasche, Frank ; Fliessbach, Andreas ; Moretti, Marco

In: Science of The Total Environment, 2019, vol. 658, p. 1614–1629

In the face of growing urban densification, green spaces in cities, such as gardens, are increasingly important for biodiversity and ecosystem services. However, the influences of urban green space management on biodiversity and ecosystem functioning (BEF) relationships is poorly understood. We investigated the relationship between soil fauna and litter decomposition in 170 urban garden sites...

Université de Fribourg

The relation between spatial thinking and proportional reasoning in preschoolers

Möhring, Wenke ; Newcombe, Nora S. ; Frick, Andrea

In: Journal of Experimental Child Psychology, 2015, vol. 132, p. 213–220

Previous research has indicated a close link between spatial and mathematical thinking. However, what shared processes account for this link? In this study, we focused on the spatial skill of map reading and the mathematical skill of proportional reasoning and investigated whether scaling, or the ability to relate information in different-sized representations, is a shared process. Scaling was...

Université de Fribourg

Whole-body regeneration in the colonial tunicate Botrylloides leachii

Blanchoud, Simon ; Rinkevich, Buki ; Wilson, Megan J.

In: Marine Organisms as Model Systems in Biology and Medicine, 2018, p. 337–355

The colonial marine invertebrate Botrylloides leachii belongs to the Tunicata subphylum, the closest invertebrate relatives to the vertebrate group and the only known class of chordates that can undergo whole-body regeneration (WBR). This dramatic developmental process allows a minute isolated fragment of B. leachii’s vascular system, or a colony excised of all adults, to restore a...