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Université de Fribourg

Reduction of nanoparticle load in cells by mitosis but not exocytosis

Bourquin, Joël ; Septiadi, Dedy ; Vanhecke, Dimitri ; Balog, Sandor ; Steinmetz, Lukas ; Spuch-Calvar, Miguel ; Taladriz-Blanco, Patricia ; Petri-Fink, Alke ; Rothen-Rutishauser, Barbara

In: ACS Nano, 2019, vol. 13, no. 7, p. 7759–7770

The long-term fate of biomedically relevant nanoparticles (NPs) at the single cell level after uptake is not fully understood yet. We report that lysosomal exocytosis of NPs is not a mechanism to reduce the particle load. Biopersistent NPs such as nonporous silica and gold remain in cells for a prolonged time. The only reduction of the intracellular NP number is observed via cell division,...

Université de Fribourg

Lock‐in thermography to analyze plasmonic nanoparticle dispersions

Steinmetz, Lukas ; Taladriz‐Blanco, Patricia ; Geers, Christoph ; Spuch‐Calvar, Miguel ; Bonmarin, Mathias ; Balog, Sandor ; Rothen‐Rutishauser, Barbara ; Petri‐Fink, Alke

In: Particle & Particle Systems Characterization, 2019, p. 1900224

The physicochemical properties of nanoparticles (NPs) strongly rely on their colloidal stability, and any given dispersion can display remarkably different features, depending on whether it contains single particles or clusters. Thus, developing efficient experimental methods that are able to provide accurate and reproducible measures of the NP properties is a considerable challenge for both...

Université de Fribourg

Synthesis and structural analysis of polynuclear silver(I) complexes with 4,7-phenanthroline

Stanojević, Ivana M. ; Savić, Nada D. ; Crochet, Aurélien ; Fromm, Katharina M. ; Đuran, Miloš I. ; Glišić, Biljana Đ.

In: Journal of the Serbian Chemical Society, 2019, vol. 84, no. 7, p. 689–699

New polynuclear silver(I) complexes, [Ag(CF3SO3)(4,7-phen)(CH3CN)]n (1) and [Ag(PO2F2)(4,7-phen)]n (2), were synthesized by the reaction of 4,7-phenanthroline (4,7-phen) and the corresponding AgX salt (X = CF3SO3 - and PF6 -) in 1:2 mole ratio, respectively, in methanol/acetone (1:1 volume ratio) at room temperature. The characterization of the complexes was established on the basis of...

Université de Fribourg

Compartmentalization of alkaline-earth metals in salen-type Cu- and Ni-complexes in solution and in the solid state

Finelli, Alba ; Hérault, Nelly ; Crochet, Aurélien ; Fromm, Katharina M.

In: ACS Omega, 2019, vol. 4, no. 6, p. 10231–10242

The precise arrangement of metal ions in type and number by a ligand represents an important challenge in biology as well as in materials science. The preorganization of different metal ions such as alkaline-earth and transition-metal ions is of particular interest for the design of catalysts or precursors of oxides. This study is based on a Ω- shaped salen-derived ligand comprising N2O2 and...

Université de Fribourg

A novel Ca2+-binding protein that can rapidly transduce auxin responses during root growth

Hazak, Ora ; Mamon, Elad ; Lavy, Meirav ; Sternberg, Hasana ; Behera, Smrutisanjita ; Schmitz-Thom, Ina ; Bloch, Daria ; Dementiev, Olga ; Gutman, Itay ; Danziger, Tomer ; Schwarz, Netanel ; Abuzeineh, Anas ; Mockaitis, Keithanne ; Estelle, Mark ; Hirsch, Joel A. ; Kudla, Jörg ; Yalovsky, Shaul

In: PLOS Biology, 2019, vol. 17, no. 7, p. e3000085

Signaling cross talks between auxin, a regulator of plant development, and Ca2+, a universal second messenger, have been proposed to modulate developmental plasticity in plants. However, the underlying molecular mechanisms are largely unknown. Here, we report that in Arabidopsis roots, auxin elicits specific Ca2+ signaling patterns that spatially coincide with the expression pattern of...

Accès public à partir du 18 janv. 2021
Université de Neuchâtel

Alternative spatial hierarchies: a cross-border spouse’s positioning strategies in the face of Germany’s ‘pre-integration’ language test

Jashari, Shpresa ; Dahinden, Janine ; Moret, Joëlle

In: Journal of Ethnic and Migration Studies, 2019, p. 1-17

This paper examines how spouses waiting in Turkey to be reunited with their partner in Europe experience border regimes and deal with the transnationalised discourses on ‘marriage migrants’ they encounter. It is based on the analysis of a single narrative interview, that of a woman taking German classes at Goethe Institute in Istanbul in order to pass the required language test. Like other...

Université de Fribourg

Laboratory based XAS measurements, electron-induced double K-shell ionization of Sc, Cr and Cu : and, Chemical sensitivity of photoinduced Kʰβ hypersatelite transition in Cr compounds

Zeeshan, Faisal ; Dousse, Jean-Claude (Dir.)

Thèse de doctorat : Université de Fribourg, 2017 ; no. 2052.

Cette thèse de doctorat contient trois différents projets qui appartiennent aux domaines de la physique atomique des couches profondes et de la spectroscopie de rayons X en haute résolution. Le premier projet concerne l’étude des spectres d’absorption (XAS) K et L de quelques éléments de transition 3d, 4d et 5d. Les mesures ont été réalisées à Fribourg avec le spectromètre à...

Università della Svizzera italiana

LPS nephropathy in mice is ameliorated by IL-2 independently of regulatory T cells activity

Bertelli, Roberta ; Di Donato, Armando ; Cioni, Michela ; Grassi, Fabio ; Ikehata, Masami ; Bonanni, Alice ; Rastaldi, Maria Pia ; Ghiggeri, Gian Marco

In: Plos one, 2014, vol. 9, no. 10, p. e111285

Immunosuppressive regulatory T cells (Tregs) have been hypothesized to exert a protective role in animal models of spontaneous (Buffalo/Mna) and/or drug induced (Adriamycin) nephrotic syndrome. In this study, we thought to define whether Tregs can modify the outcome of LPS nephropathy utilizing IL-2 as inducer of tissue and circulating Tregs. LPS (12 mg/Kg) was given as single shot in C57BL/6,...

Université de Fribourg

Plasmon-assisted Förster resonance energy transfer at the single-molecule level in the moderate quenching regime

Bohlen, J. ; Cuartero-González, Á. ; Pibiri, E. ; Ruhlandt, D. ; Fernández-Domínguez, A. I. ; Tinnefeld, P. ; Acuna, Guillermo P.

In: Nanoscale, 2019, vol. 11, no. 16, p. 7674–7681

Metallic nanoparticles were shown to affect Förster energy transfer between fluorophore pairs. However, to date, the net plasmonic effect on FRET is still under dispute, with experiments showing efficiency enhancement and reduction. This controversy is due to the challenges involved in the precise positioning of FRET pairs in the near field of a metallic nanostructure, as well as in the...