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Université de Fribourg

Initiated by CREB: resolving gene regulatory programs in learning and memory: switch in cofactors and transcription regulators between memory consolidation and maintenance network

Kaldun, Jenifer C. ; Sprecher, Simon G.

In: BioEssays, 2019, vol. 41, no. 8, p. 1900045

Consolidation of long‐term memory is a highly and precisely regulated multistep process. The transcription regulator cAMP response element‐binding protein (CREB) plays a key role in initiating memory consolidation. With time processing, first the cofactors are changed and, secondly, CREB gets dispensable. This ultimately changes the expressed gene program to genes required to maintain the...

Université de Fribourg

Adaptation to fluctuating environments in a selection experiment with Drosophila melanogaster

Kubrak, Olga I. ; Nylin, Sören ; Flatt, Thomas ; Nässel, Dick R. ; Leimar, Olof

In: Ecology and Evolution, 2017, vol. 7, no. 11, p. 3796–3807

A fundamental question in life‐history evolution is how organisms cope with fluctuating environments, including variation between stressful and benign conditions. For short‐ lived organisms, environments commonly vary between generations. Using a novel experimental design, we exposed wild‐derived Drosophila melanogaster to three different selection regimes: one where generations...